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Öğe Assessing the quality of randomized controlled trials from two leading cancer journals using the CONSORT statement.(2008) Süt N.; Senocak M.; Uysal O.; Köksalan H.BACKGROUND: No study has been conducted on the scientific quality of randomized controlled trials (RCTs) in the cancer field. Our objective was to determine whether adherence to the Consolidated Standards for Reporting Trials (CONSORT) statement is associated with scientific properties of RCT reports from two leading cancer journals. METHODS: We conducted an observational study of RCTs published between 2002 and 2004 in two leading cancer journals that did not endorse the CONSORT statement during that period. We determined the adherence rates with confidence intervals of 33 RCTs according to the 19 methodological items of the CONSORT statement. Each RCT was blindly assessed by three independent evaluators; then the evaluators examined all judgments sequentially and obtained a consensus regarding each methodological item of the CONSORT statement. RESULTS: The average adherence of these 33 RCTs to the 19 methodological items of the CONSORT statement was 79.3% (95% CI, 75.3-83.4%). Most descriptors from the checklist were determined to be methodologically adequate except sequence generation (56.1%; 95% CI, 40.9-71.3%), allocation concealment (27.3%; 95% CI, 13.2-41.4%), implementation (7.6%; 95% CI, 0.0-15.4%), blinding (30.3%; 95% CI, 14.4-46.3%) and sample size (74.2%; 95% CI, 59.5-89.0%). Of all CONSORT checklist items, randomization implementation was the most often omitted. CONCLUSION: Some key methodological items of the CONSORT statement seem poorly addressed in RCTs from these leading cancer journals. Thus researchers should be urged to conform to the CONSORT statement when reporting on RCTs, and the poorly addressed items of the CONSORT statement should be reevaluated for RCTs already reported.Öğe Comparison of sufentanil and remifentanil during monitored anesthesia care(2003) Turan A.; Erk Köse H.; Karamanlio?lu B.; Süt N.; Günday I.In our study we aimed to compare remifentanil and sufentanil in monitored anesthesia care of septoplasty operations for consumption of propofol, analgesia, sedation and side effects. 50 patients scheduled for septoplasty operations were randomily divided into two groups of 25 patients in each received standardised premedication. Induction of sedation was done by 0.8 mg kg-1 propofol. Continoued by 2 mg kg-1 hr-1 and adjusted according to sedation scale. In Group 0.05 ?g kg-1 dk-1 remifentanil, in group II 0.25 ?g kg-1 hr-1 sufentanil infusion was started and adjusted according to scores of visuel rating scale. Intraoperative mean blood pressure, heart rate, SpO2 and visuel rating scale were evaluated and recorded at 5., 10., 20., 30., 40., and 50. mins. At the end of surgery study drugs were ended and total propofol, remifentanil, sufentanil consumptions were recorded. Alderete scores were evaluated 3 times at 15. min. interval after the termination of study drug. Intraoperative surgeon evaluation was done by 4 point scale. Postoperative 1., 2., 4., 6., 12. and 24. hrs mean blood pressure, heart rate, SpO2 and pain was evaluated by visual analog scale (VAS). When VAS scores were 4 or above 75 mg intramuscular diclophenac was given, first analgesic requirement time and total diclophenac consumptions were recorded. Total propofol consumptions were significantly high in group I when compared with group II (p<0.05). Aldrete scores in 15. min was lower in group II (p<0.05). Postoperative VAS values at 2. and 4. hrs were found to be higher in group I (p<0.05). First analgesic requirement time was significantly prolonged in group II (p<0.05), while there was on significant diffference in total diclophenac consumption. Respiratory depression and headache was encountered more in group I and difference was significant (p<0.05). Sufentanil infusion can be an alternative to remifentanil infusion in monitored anesthesia care.Öğe Effect of intraperitoneal bupivacaine and bupivacaine+meperidine infiltration on postoperative pain in total abdominal histerectomy(2002) Memiş D.; Turan A.; Karamanlio?lu B.; Güler T.; Süt N.; Pamukçu Z.We aimed to evaluate; intraperitoneal application of bupivacaine and bupivacaine+meperidine combinations effects on postoperative vital parameters and pain in total abdominal histerectomy. Our study is done on 28 patients scheduled for abdominal hysterectomy. In Group I (n=14) 20 mL bupivacaine % 0.5, to Group II (n=14) 20 mL bupivacaiae % 0.5+50 mg meperidine was given into peritoneal cavity according to infiltration rules. Postoperative pain was evaluated, 30 min, and 2,4,6,12,24 hours after excubation with, VAS while patients were laying and seated. Side effects were noted. When patients were laying at 30. mi and 2. hours (p<0.01) and while seated 30 min, VAS values were found to be statistically significantly low in Group II when compared with Group 1 (p<0.01). Consumption of meperidine was found 56.67±10.11 mg in Group I, and 50 mg in Group II, there was significant difference between them (p<0.01). First analgesic time found 30 min in Group I and 155±81.7 min in Group II, difference was found between groups (pÖğe The effect of linear polarized polychromatic light therapies applied according to biochemical values on pressure ulcers(2007) Özdemir F.; Rodoplu M.; Oymak F.; Süt N.Objective: Pressure ulcer is an important health problem of immobile and especially bedridden patients. In the study we assessed the effect of linear polarized polychromatic light therapies on pressure ulcers according toto albumin level, anemia and diabetes mellitus presence. Materials and Methods: Twenty patients were included in this study who were hospitalized in departments of physical therapy and rehabilitation, neurology and plastic and reconstructive surgery. Patients included in the study had stage II or stage III pressure ulcers. Albumin and hemoglobin levels and presence of diabetes mellitus of all subjects were recorded at the beginning of the study. Routine wound care were applied to all subjects. In addition, linear polarized polychromatic light was applied directly through the skin with 1.3 J/cm2 energy dosage of Biolamp device for 6 minutes daily from a distance of 10 cm. Ulcer area measurements were made using a scaled paper at 1st, 7th and 15th days of treatment and expressed as square centimeters. Results: We did not find statistically significant difference between groups in wound area at 1st, 7th and 15th days when compared groups according to albumin and hemoglobin levels and presence of diabetes mellitus (p>0.05). When investigated the correlation between wound improvement and hemoglobin and albumin levels we found negative correlation between albumin level and wound improvement. Conclusion: These results suggest that the effect of linear polarized polychromatic light therapy was not affected by biochemical parameters. These results may reflect the positive biomodular effect of linear polarized polychromatic light. We concluded that although the biochemical parameters did not effect the treatment, we have to attach importance the biochemical parameters or the addition problems.Öğe The effects of dexmedetomidine on shivering and the change of the body temperature under general anesthesia and epidural block(2007) Karaçayir Y.; Arar C.; Çolak A.; Pamukçu Z.; Süt N.Pharmacological agents are choosen for the treatment of postoperative shivering. Clinical studies are going on to find perfect agent with low side effects. In our study we aimed to investigate the effects of dexmedetomidine infusion on postoperative shivering and the change of the body temperature during general anesthesia and epidural ansthesia. Patients were randomly divided into two goups; Group I (n=50) receiving general anesthesia and Group II (n=50) epidural anesthesia. After induction of general anesthesia Group I was divided into two subgroups. Similarly Group II was divided into two subgroups when the block reached to the T 6 level. Group IA and Group IIA were administered saline solution, where Group IB (n=25) and IIB received 2 ?g mL -1 prepared dexmedetomidine solution, 0.25 mL kg -1 hr -1 dexmedetomidine infusion was administered for 10 minutes subsequently 0.1 mL kg -1 hr -1 infusion for maintenance. The heart rate (HR), systolic arteriel pressure (SAP), diastolic arteriel pressure (DAP), peripheral oxygen saturation (SpO 2) tympanic membrane temperature of all patients were recorded after induction or block and at 30, 60, 90 th minutes. In Group II sedation scores were also recorded. HR, SAP, DAP, SpO 2 tympanic, membrane temperature, shivering scores, sedation scores were recorded post operative at 15, 30, 60 th minutes. The patients who had shivering score more than 3 were administered intravenous 25 mg meperidin. The dosage and times of meperidin given were recorded. Postoperative 60 th minute the patients who have Aldtrete score of 9 were externed to their services. In Group IA compared group IB intraoperative 30 th minute and 90 th minute HR and DAP values and intraoperative 30, 60, 90 th minutes tympanic membrane values were found lower (p<0.05). No statistically significant differences were determined between the postoperative groups with respect to hemodynamic values, tympanic membrane temperature, sedation levels, shivering scores, nause and vomiting, mepcrdin consumption and side effects. VAS was found significantly higher in GroupI than GroupII (p<0.05). The mean ages of patients with shivering score ?3 were lower than the ones with shivering score <3, but the sexualities were found similiar. In conclusion, we found that the infusion of dexmedetomidine decreased the body temperature and hemodynamic values with the dose we used intraoperatively on the cases under general anesthesia, but on the other hand we didn't observe these effects under epidural anesthesia.Öğe Evaluation of high intensity interval training effects on cytokine levels and clinical course in heroin addicts(Cukurova University, Faculty of Medicine, 2019) Taş Dürmüş P.; Vardar M.E.; Kaya O.; Tayfur P.; Süt N.; Vardar S.A.Objective: The aim of study was to evaluate the effects of high intensity interval training (HIIT) on depression, anxiety, craving and cortisol, IGF-1, IFN-?, IL-17 levels in heroin addicts. Methods: Twenty-two male inpatients who met the criteria for opiate use disorder were included in study. Participants were divided into two groups as exercise and control. We were applied five sessions of HIIT in exercise group. Hamilton Depression and Anxiety Scale, Substance Craving Scale were administered at the beginning and end of treatment; cortisol, IGF-1, IFN-?, IL-17 levels were also measured. Results: There was significant improvement in Hamilton Depression and Anxiety Scale, Substance Craving Scale scores in the exercise group. Cortisol and IGF-1 levels could be increased in the exercise group, whereas IFN-? and IL-17 levels were not significantly different. Discussion: It was thought that this study could contribute to literature by emphasizing the effects of HIIT in patients treated with diagnosis of heroin addiction. © 2019, Cukurova University, Faculty of Medicine. All rights reserved.Öğe Healthy lifestyle behaviors of nursing and classroom teaching students(Gulhane Military Medical Academy, 2014) Kostak M.A.; Kurt S.; Süt N.; Akarsu Ö.; Ergül G.D.AIM: The aim of this descriptive study is to assess the healthy lifestyle behaviors (HLSB) of nursing and classroom teaching students and to identify factors which affect these behaviors. METHODS: The sample of the study consisted of Faculty of Health Sciences nursing students (n=158); Faculty of Education of classroom teaching students (n=180). Data were collected with a "Questionnaire Form" developed by researchers and The Healthy Lifestyle Behaviors Scale II. Data were analyzed using percentage, the mean, standard deviation, Mann-Whitney U test and chi-square test. RESULTS: As a result of the study Healthy Lifestyle Behaviors Scale average scores of female students were higher than male students; those with better health status were higher than those with moderate health status and poor health status; those with a good level of success were higher than those with moderate level of success and poor level of success; those who received courses related to health promotion were higher than who did not receive; those who stopped smoking were higher than those nonsmokers and smokers; those students who participated in sports activities were higher than that did not participate (p<0.05). CONCLUSIONS: In this study, students' gender, health status, level of success, taking courses related to health promotion, smoking and their participation in sports activities influenced the behavior of healthy lifestyle.Öğe Isolated fetal intracardiac hyperechogenic focus associated with neonatal outcome and triple test results(2007) Arda S.; Sayin N.C.; Varol F.G.; Süt N.Objective: To investigate the relationship between isolated intracardiac hyperechogenic focus (IHF) in the mid trimester of pregnancy with neonatal outcomes and triple test results. Materials and methods: The study included low-risk pregnant women who came for routine follow-up to our antenatal clinic between years 2000 and 2005. A detailed structural survey by ultrasound (USG) of the fetal heart was performed on each fetus in the mid-trimester of pregnancy. All patients had mid-trimester triple tests performed between the 16th and 18th weeks' of pregnancy. We recruited a total of 40 pregnancies that had fetal IHF in the level II USG examination and a control group of 100 healthy pregnant women those which were followed-up during the same period. Twenty-nine fetuses (72.5%) had left, 8 (20%) had right whereas 3 (7.5%) had bilateral ventricular IHF. We compared the perinatal and neonatal outcomes and triple test results of the fetuses that had right and left IHF, and the controls. Results: Cytogenetic amniocentesis was performed to 6 (15%) women in the study and 5 (5%) in the control group and all were normal. During follow-up IHF spontaneously disappeared in 30 fetuses [right (n: 5), left (n: 23) or bilateral (n: 2)]. We did not observe any cardiac problem in the postnatal period in all newborns. Only one infant (2.5%) in the study group was admitted to neonatal intensive care unit because of prematurity. Median delivery weeks (P = 0.023), head circumference (P = 0.013), 5-min Apgar score (P = 0.021] and apnea (P = 0.042) were significantly higher in fetuses with right IHF. Compared to the controls, median delivery weeks (P = 0.038) was significantly higher in fetuses with right IHF, but head circumference (P = 0.004), 1-min (P = 0.003) and 5-min (P < 0.001) Apgar scores were lower in fetuses with left IHF. However no difference was observed in second-trimester serum human chorionic gonadotropin (HCG), alpha-fetoprotein (AFP) and estriol (E3) levels, in the three groups. There was no correlation between serum HCG, AFP and E3 levels and the presence of IHF. Conclusions: Isolated IHF in the fetal heart in the mid-trimester of pregnancy seems not associated with adverse neonatal outcome and does not correlate with triple test results. © 2007 Springer-Verlag.Öğe Obesity Risk Factors in Turkish Children(2009) Garipagaoglu M.; Budak N.; Süt N.; Akdikmen Ö.; Oner N.; Bundak R.On the basis of the knowledge that the prevalence of obesity in children has increased steadily in recent years, this study aimed to assess the association between obesity and certain risk factors in a group of 6- to 14-year-old children living in Istanbul. The study was carried out at the Istanbul University School of Medicine Hospital. Data were collected from 592 children aged between 6 and 14 years who were examined in general pediatrics clinics. Weight and height measurements were performed on the children and their parents. The children were classified as obese and nonobese in accordance with the body mass index reference values for Turkish children. Energy intake of children was estimated with a 3-day food consumption recording form. A structured questionnaire was used to collect the information from the parents on possible risk factors causing obesity. The physical activity state of the children was assessed. A logistic regression model was developed to examine the relationships between obesity and possible risk factors. Almost 32% (n = 184) and 69% (n = 408) of children were assessed as obese and nonobese, respectively. Although there was no difference in daily energy intakes of obese and nonobese children, 13.6% of obese and 40.9% of nonobese children were reported to do physical activity regularly. Obesity was strongly associated with parental obesity. Furthermore, energy intake; having regular physical activity; presence of obesity in the mother, the father, and the mother's family; and having a mother working out of home were also significantly associated with obesity. Creating awareness in mothers on the importance of a healthy nutrition and encouraging families to participate in physical activities are important points in the prevention of childhood obesity. © 2009 Elsevier Inc. All rights reserved.Öğe P 132 – In postmenopausal period: How are balance and posture affected?(Elsevier B.V., 2018) Akgül H.; Demirbağ Kabayel D.; Uluçam E.; Süt N.[No abstract available]Öğe Prevalance of the urinary incontinence in women older than 40 years and influence of their QoL(2010) Akgün G.; Süt N.; Balkanli Kaplan P.Objective: To investigate the frequency of urinary incontinence that appears in women in their declining years and to what degree their qualities of life are affected by this problem. Material and Methods: Study was conducted with women over 40 years in 5 clinics that serve affiliated to Kirklareli provincial centre between the October 2007 and January 2008. A 27-question- questionaire developed by the researcher in order to define socio-demographic characteristics, risk factors that cause incontinence was applied. Furthermore, Incontinence Quality of Life questionnaire (IQOL) was also applied to women who had a complaint of urinary incontinence for defining the level of quality of life of the women. Results: Urinary continence was found 48.3% of the women population over 40 years that researched. We showed that the quality of life of the women with urinary incontinence did not affected that much. It was found out that the rise in age, birth number, and body mass index in women with incontinence resulted in significant declining in quality of life of these women. We also shown that quality of life of women with incontinence did not affected by the lenght of the urinary incontinence symptom process. Conclusion: Although, we estimated that the urinary incontinence affect women's life quality in a low degree, it is an important health problem that influence nearly fifty percent of the women over 40 years old. Copyright © 2010 by Türkiye Klinikleri.Öğe The prognostic value of atrial and brain natriuretic peptides, troponin I and C-reactive protein in patients with sepsis(2008) Yucel T.; Memiş D.; Karamanlioglu B.; Süt N.; Yuksel M.Aim: To investigate the plasma levels of atrial and brain natriuretic peptides (ANP and BNP), cardiac troponin I (cTnI) and C-reactive protein (CRP) as prognostic factors for survival in patients with sepsis. Method: Evaluation of serum levels of ANP, BNP, cTnI and CRP of patients an admission to an intensive care unit, two days later, and on the day of discharge from the intensive care unit or on the day of death. Results: ANP levels were significantly higher in the nonsurviving patients (day 1: 70.00±49.54 pg/mL; day 2: 138.85±143.15 pg/mL; and died/discharged day: 375.70±262.66 pg/mL) than surviving patients (day 1: 23.96±29.93 pg/mL; day 2: 10.06±6.03 pg/ML; died/discharged. day: 6.68±100.98 pg/mL, P<0.001). The BNP levels were significantly higher in the nonsurvivors (day 1: 254.78±308.62 pg/mL; day 2: 383.22±307.19 pg/mL; and died/discharged day: 696.47±340.33 pg/mL), than survivors (day 1: 13.72±12.95 pg/mL; day 2: 7.20±5.85 pg/mL; died/discharged day: 4.51±4.64 pg/mL, P<0.001). The cTnI levels were significantly higher in the nonsurviving patients (day 2: 0.16±0.38 ?g/L; died/discharged day: 0.78±2.48 ?g/L) than surviving patients (day 2: 0.04±0.07 ?g/L; died/discharged day: 0.02±0.01 ?g/L, P<0.05). The CRP levels were significantly higher in the nonsurvivors (day 2: 119.3±71.5 mg/L; and died/discharged day: 145.7±74.7 mg/L) than sumavors (day 2: 57.0±29.7 mg/L; died/discharged day: 26.8±24.0 mg/L, P<0,05). There were no significont differences between nonsurvivors and survivors for cTnI and CRP on day 1. Conclusion: With the exception of cTnI and CRP on day 1, all of the parameters were significantly powerful to determine nonsurvivors on all days. Among these variables, BNP was the most powerful diagnostic parameter for the prediction of nonsurvivors on all days. © 2008 Pulsus Group Inc. All rights reserved.Öğe The relationship between the results of osteoporosis risk test and bone mineral density(2009) Özdemir F.; Kabayel D.D.; Süt N.; Koçan D.K.; Yazici Ş.D.; Uzunali M.Aim: The importance of questions for determining osteoporosis (OP) and T score; and the relation between bone mineral density (BMD) and the one-minute OP risk test which is used for evaluating the risk factors of patients for OP, were examined. Material and Methods: 206 postmenopausal women, who applied to OP clinic for the first time, were recruited. One-minute OP risk test was carried out to all patients. The answers of the questions were 'Yes' or 'No'. Having recorded from lumbar spine and femur neck by dual energy x-ray absorptiometry (DXA) the BMD values, and T scores were evaluated. Spearman correlation test. Logistic and Linear regression tests were used for the statistical analyses. Results: The question 4 (has your height shortened over 3 cm?) was statistically significant for determining the OP in femur neck (Odds ratio 3.14, %95 Cl, 62-6.11). The questions 3 (have you ever taken corticosteroids over 3 months?) and 4 were significant for T score in femur neck (p<0.011, Std ?=181 and p=0.027, Std ?=0.157, respectively). A statistically significant negative correlation between the number of 'Yes' in the risk test and BMD in the femur neck was seen (p<0.001). No correlation was found between the result of risk test and BMD value of lumbar spine and T scores. Conclusion: The results of the one-minute OP risk test were particularly related to DXA results of femur neck.Öğe The role of Asprosin in the diagnosis of diabetic and non-diabetic patients with sepsis(Pharmamed Mado Ltd, 2024) Salt S.A.; Aydoğdu N.; Salt Ö.; Fırat N.; Süt N.Sepsis is among the major causes of mortality in the world due to its delayed diagnosis and inadequate treatment. Due to the high morbidity and mortality rates, a widely accepted biomarker is required for its diagnosis. Present study aimed to evaluate the serum asprosin levels in septic patients and determine its potential use as a biomarker for its diagnosis. A prospective cohort study was performed with total 81 participants. These were divided in two groups, i.e., 54 septic patients and 27 healthy volunteers (control group). Among 54 septic participants, half (27) were diabetic, and half (27) were nondiabetic. Blood samples (3 mL) were collected from the control group and the patients who were diagnosed with sepsis and transferred to serum seperator tube. Samples were fractioned and stored at ?80? C for further evaluation. These samples were used for the measurement of serum asprosin levels. Demographic characteristics and laboratory data of the patients were recorded in the study form prepared previously. The serum asprosin levels in the control group were 4.1 ± 1.4 ng/mL, 32.8 ± 7 ng/mL in the non-diabetic septic patients and 90.7 ± 5.5 ng/mL in diabetic septic patients. The asprosin level in the non-diabetic group were higher as compared to the control group (p: 0.012), and it was statistically significantly higher in the diabetic group compared to the non-diabetic septic and control groups (both: p < 0.001). Serum asprosin levels were significantly higher in patients with sepsis specially having diabetes. Serum asprosin levels may be beneficial for the diagnosis of sepsis especially in diabetic patients along with the other laboratory parameters white blood cells (WBC), C-reactive protein (CRP), sequential organ failure assessment score (SOFA score) and fewer. © 2024 The Author(s).Öğe Self-assessment of articles published in the Balkan medical journal according to their study design with regards to impact factor(Galenos Publishing House, 2020) Kizilkaya O.; Süt N.; İnan M.[No abstract available]Öğe Sleep quality assessment in adolescents with and without Type 1 diabetes using the pittsburg sleep quality index(Wolters Kluwer Medknow Publications, 2021) Çömlek F.O.; Çelik H.; Keskin B.; Süt N.; Dilek E.; Tütüncüler F.Background and Aims: Many diseases, especially chronic diseases, can lead to sleep disturbances. Our study aimed to evaluate sleep characteristics and the relationship between sleep disorders and diabetes-related variables in type 1 diabetes adolescents and to compare these results with a non-diabetic group of similar age and gender. Methods: This cross-sectional study collected data from 40 healthy adolescents and 50 patients of the same age group with type 1 diabetes mellitus from January 2019 to June 2019. Subjects were asked to complete the Pittsburgh Uyku Kalitesi Anketi (PUKA). Patients who had nocturnal hypoglycemia in the preceding one month were excluded. Results: Total scores for PUKA were not significantly different between the two groups (P = 0.197). No significant relationship was found between sleep quality, duration of diabetes, and HbA1c levels in the diabetes group (P = 0.59, P = 0.41, respectively). Poor sleep quality (PUKA score ?5) in girls without diabetes was higher (95% confidence interval: 1.26-11.61) than in the diabetes group (P = 0.031). Conclusion: In our study, the prevalence of sleep disorders in T1D patients was not higher than the non-diabetic population. However, the girls in the non-diabetic group had significant poor sleep quality. We hypothesize that this may be due to diabetes management bringing order and discipline to an adolescents life. © 2021 Medknow. All Rights Reserved.
