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Öğe Comparison of interpleural bupivacaine plus adrenaline to bupivacaine plus adrenaline plus morphine injections in postoperative analgesia(1995) Kirmemis M.; Gunday I.; Karamanlioglu B.This study was performed on 20 ASA I-II patients operated with subcostal incision. The cases were divided into two groups to investigate the quality and the time course of two different combinations of analgesics. Interpleurally, bupivacaine (0.5 %, 150 mg) plus adrenaline (1/200.000, 0.15 mg) were administered to group I (n=10), and bupivacaine (0.5 %, 150 mg) pills adrenaline (1/200.000, 0.15 mg) plus morphine (2 mg) were administered to group II (n=10). Forced vital capacity (FVC) and forced expiration volume in the first second (FEV1) were measured before the premedication (stage I) in, both groups. Following surgical intervention; Visual analogue scala (VAS), FVC and FEV1 values were measured before the blockade (stage II), 30 minutes (stage III) and 120 minutes (stage IV) after the blockade respectively in both groups. In both groups, 1) VAS values decreased significantly at stages III and IV. 2) FVC and FEV1 values were found lower in stage II than stage I. Although the values obtained in the stages III and IV could not reach the values of stage I, FVC and FEV1 values showed improvement. There were no significant differences between group I and II in terms of VAS, FVC and FEV1. In group II, analgesia started significantly earlier and lasted significantly longer. As a result, interpleural injection of bupivacaine plus adrenaline after subcostal incision produced sufficient analgesia and helped to improve the impaired respiratory functions. An additional dose of morphine (2 mg) to bupivacaine and adrenaline injections (group II) caused analgesia to start earlier and last longer which may be a reason for preference.Öğe A comparison of oral midazolam, oral tramadol, and intranasal sufentanil premedication in pediatric patients(Weston Medical Publishing, 2007) Bayrak F.; Gunday I.; Memis D.; Turan A.Background: This study was designed to evaluate the efficacy and safety of oral midazolam, tramadol drops, and intranasal sufentanil for premedication of pediatric patients. Methods: Sixty children, three to 10 years of age, who were designated as American Society of Anesthesiologists physical status I and who were undergoing adenotonsillectomy as inpatients were randomized to receive a dosage of 0.5 mg/kg (total of 4 mL) midazolam in cherry juice (n = 20, Group M), 3 mg/kg tramadol drops (n = 20, Group T), or 2 ?g/kg intranasal sufentanil (n = 20, Group S). Clinical responses (sedation, anxiolysis, cooperation) and adverse effects (respiratory, hemodynamic, etc.) were recorded. Safety was assessed by continuous oxygen saturation monitoring and observation. Vital signs (blood pressure, pulse, oxygen saturation, respiratory rate) were recorded before drug administration (baseline) and then every 10 minutes until the induction of anesthesia. Results: Mean blood pressure decreased significantly after five minutes of intranasal sufentanil administration relative to Groups M (p < 0.01) and T (p < 0.05), whereas heart rate remained unchanged. Oxygen saturation and respiratory rate decreased significantly after 20 and 30 minutes of intranasal sufentanil administration relative to Groups M and T (p < 0.05). Anxiety scores showed rates of 45 percent in Group M, 5 percent in Group T, and 40 percent in Group S. Anxiety scores in Groups M and S were better than those of Group T (p < 0.01). Cooperation scores for face-mask acceptance showed rates of 85 percent in Group M, 45 percent in Group T, and 85 percent in Group S (p < 0.01). Conclusion: Intranasal sufentanil and oral midazolam are more appropriate premedication options than tramadol drops in children.Öğe Comparison of the effects of propofol and thiopentone on renal functions(1990) Kosanoglu S.; Gunday I.; Sengonul O.[No abstract available]Öğe Effect of famotidine on gastric pH and free acid volume during general anaesthesia(1990) Esen E.; Gunday I.; Sengonul O.[No abstract available]Öğe Effect of magnesium sulfate infusion on sevoflurane consumption, hemodynamics, and perioperative opioid consumption in lumbar disc surgery(Weston Medical Publishing, 2008) Oguzhan N.; Gunday I.; Turan A.Background: Magnesium sulphate administration was initially reported to reduce postoperative analgesic requirements. Subsequent reports, though, were inconsistent. Specifically, we tested the hypotheses that intraoperative magnesium sulfate administration reduces postoperative requirement for opioids, secondary outcomes were intraoperative muscle relaxant, sevoflurane consumptions and postoperative pain. Methods: Fifty American society of anesthesiology status (ASA) I-II patients who gave a written informed consent were scheduled for elective lumbar disc surgery. The Institutional Review Board approved the study. Patients were randomly assigned to the placebo group (n = 25) or magnesium group (n = 25). Patients assigned to the magnesium group were given an initial infusion of 30 mg/kg (over 10 minutes) starting immediately after anesthesia and completed before intubation. The infusion was then continued at 10 mg/kg/hr throughout surgery. General anesthesia was induced with propofol, 2.5 mg/kg, and maintained with sevoflurane 2 percent in a 50 percent O2/50 percent N2O mixture. The sevoflurane concentration was adjusted to keep bispectral index (BIS) values between 45 and 60. Both groups were given atracurium, 0.6 mg/kg, and a remifentanil infusion at an initial dose of 0.1 mg/kg/h. The remifentanil infusion was adjusted to maintain heart rate and mean arterial pressure (MAP) within 20 percent of baseline values. Atracurium administration was repeated when the train of four (TOF) ratio exceeded 0.30. Intubation conditions were scored. At the end of surgery, the authors assessed recovery using early recovery criteria and Aldrete recovery scores. Postoperative analgesia was maintained with morphine via patient-controlled analgesia. Results: Heart rate, MAP, and pulse oximetry (SPO2) values were similar in the groups at all times. Intubating conditions were similar except that the increase in MAP was greater in the placebo group. Neither BIS values nor sevoflurane consumption differed between the groups; however, significantly less atracurium [95% CI = 4.1 (2.8, 5.5)] and remifentanil [95% CI = 0.14 (0.07, 0.20)] was used in the magnesium group. Side effects, Aldrete scores, and early recovery parameters were all similar in the groups. In the first 24 hours, visual analogue scale (VAS) values for pain were greater in the placebo than in the magnesium group. The magnesium group consumed significantly less morphine[95% CI = 11 (6, 16)]. Conclusion: Intraoperative magnesium administration significantly reduced muscle relaxant and opioid requirements; more importantly, it also reduced postoperative pain and opioid use.Öğe The effect of midazolam on the levels of serum cortisol, fasting blood sugar, liver enzymes and apnea(1990) Karamanlioglu B.; Gunday I.; Sengonul O.[No abstract available]Öğe Effect of propofol on serum levels of total lipid, cholesterol and triglyceride(1992) Sinikoglu N.; Gunday I.; Karamanlioglu B.; Sengonul O.[No abstract available]Öğe A postoperative case with aplastic anemia (Case report)(1992) Karamanlioglu B.; Pamukcu Z.; Gunday I.; Sengonul O.; Vural O.A male case, 21 years old, was diagnosed to have an aplastic anemia, immediately after an inguinal hernie surgery during which a chloramphenicol ointment was applied on to his eyes. It was thought chloramphenicol is the reason for this case's aplastic anemia by the idiosyncrotic reaction. Therefore this case is reported under the light of the relevant upto date references.Öğe Role of ?-tocopherol (vitamin E) in preventing halothane hepatotoxicity(1991) Gunday I.; Kutlu K.; Sengonul O.[No abstract available]
