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Öğe Antinuclear, Cytoskeletal, Antineuronal Antibodies in the Serum Samples of Children with Tic Disorders and Obsessive Compulsive Disorders(Galenos Publ House, 2011) Gorker, Isik; Demir, Gulsen Akman; Polat, Nuray Gurel; Omeroglu, Rukiye Eker; Icoz, Sema; Serdaroglu, Piraye; Tuzun, UmranObjective: As environmental factors, the role of Group A beta hemolytic streptococcus infections in the development of tic and obsessive compulsive disorders (OCD) is controversial. The autoimmune hypothesis states that during infection, formation of autoantibodies leads to an autoimmune disorder, which in turn results in movement disorders, tic disorders and/or OCD. In order to test this hypothesis, we assayed these antibodies in children and adolescents diagnosed with tic disorders and/or OCD. Material and Methods: Children and adolescents who were diagnosed with either tic disorders or OCD according to DSM-IV criteria (n=28), were compared with healthy controls (n=15) having similar age and gender characteristics. Regardless of a streptococcus infection history, serum samples of all patients and controls underwent antinuclear, cytoskeletal, and antineuronal antibody assay using indirect immunofluorescence. Results: The rates of antinuclear antibody positivity were 21% and 20% in the patient and control groups respectively (p>0.05). Antineuronal antibody was positive in 2 (7%) of 28 patients versus in 1 (6%) of 15 controls (p>0.05). Conclusion: These results suggest that such antibodies may not be involved in the pathogenesis of tic disorders/OCD.Öğe ASSESMENT OF COGNITIVE FUNCTIONS AND COMORBID PSYCHIATRIC DISORDER IN CHILDREN AND ADOLESCENTS DIAGNOSED WITH CONGENITAL HYPOTHYROIDISM(Elsevier Science Inc, 2016) Yildiz, Nazike; Gorker, Isik; Demir, Nuran[Abstract Not Available]Öğe Assessment of Psychiatric Comorbidity and WISC-R Profiles in Cases Diagnosed with Specific Learning Disorder According to DSM-5 Criteria(Aves, 2018) Altay, Menguhan Araz; Gorker, IsikIntroduction: In this study, the frequency of psychiatric comorbidity in children and adolescents who were diagnosed with specific learning disorder, the factors that affect the frequency of comorbidity, the subtypes of specific learning disorder and the effects on cognitive profile have been investigated. Methods: Our study was performed among 80 cases with the age range 6-15 years who diagnosed with specific learning disorder Child and Adolescent Psychiatry Department between January and June 2015. In the study, DSM-IV Based Screening and Evaluation Scale for Child and Adolescent Behavioral Disorders, Specific Learning Disability Evaluation Scale and the WISC-R test were performed. During the interview, reading-writing-math abilities evaluation list (error analysis) was performed in order to define the specific learning disorder subgroup and to evaluate the detailed error profile of the specific learning disorder subgroup. Kiddie Schedule for Affective Disorders and Schizophrenia for School-age Children-Present and Lifetime Turkish Version (KSADS) was performed to detect psychiatric comorbidity diagnoses. Results: 92.5% of the cases have a comorbid psychiatric disorder. The most frequent psychiatric comorbidity was attention deficit hyperactivity disorder (82.3%), followed by specific phobia (46.3%), oppositional defiant disorder (26.3%), enuresis (25%) and tic disorders (22.5%). Psychiatric comorbidity is detected more often in patients with specific learning disorder accompanied by attention deficit and hyperactivity disorder. The most frequent subtype of specific learning disorder is combined type disorder consisting of reading, writing and math disorder (37.5%). The WISC-R score of the patients who had math disorder were found to be lower than the others, and also it was detected that they learned reading and writing later, and have more comorbid psychiatric disorders. Conclusion: The results of our study indicate that associated psychiatric disorders are frequent with specific learning disorder. Specific learning disorder should not be considered as a single disorder, but should be assessed and treated with comorbid psychiatric disorders.Öğe Atomoxetine Treatment in a Patient with the Comorbidity of Attention Deficit Hyperactivity Disorder and Fragile X Syndrome(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2019) Okyar, Esra; Bozatli, Leyla; Gorker, IsikFragile X Syndrome is a genetic disease defined by cognitive and behavioral characteristics that accompany apparent physical features. Male individuals are affected by this syndrome more severely, and it is the most common cause of mental retardation in men. The most common accompanying psychiatric conditions are mental retardation, autism, Attention Deficit Hyperactivity Disorder (ADHD), anxiety disorder, depression, sleep disorders and aggression. Anxiety, depression, shyness and social withdrawal are more common in female individuals. The diagnosis and treatment of the ADHD and selective mutism in a female adolescent patient who was Fragile X full mutant will be discussed in this case report.Öğe A Case of Cerebellar Mutism after Posterior Fossa Surgery(Galenos Yayincilik, 2012) Gorker, Isik; Cobanoglu, Sabahattin; San, VolkanCerebellar mutism consisting of disruption speech output, hypotonia, ataxia, and emotional lability occurs after surgery for posterior fossa tumors. Although the mutism is transient, speech rarely normalizes and this condition is associated with adverse neurological, cognitive and psychiatric abnormalities. Possible mechanisms for its etiology include direct injury from surgical trauma, vasospasm, edema and hydrocephalus causing delayed injury to the cerebellar vermis, brainstem and dentate nuclei. In this study, the case of an adolescent patient, who had an astrocytoma and showed symptoms of cerebellar mutism, apathy, ataxi, hemiparesis and visual impairment after posterior fossa surgery, is presented. (Archives of Neuropsychiatry 2012; 49: 320-322)Öğe Clinical exome sequencing reveals an important role for clinical diagnosis of intellectual disability with definition of seven novel variants(Asean Neurological Assoc, 2023) Yalcintepe, Sinem; Gorker, Isik; Bozatli, Leyla; Guler, Hazal Sezginer; Zhuri, Drenushe; Demir, Selma; Atli, Emine IkbalIntellectual disability can be defined as a significantly below-average general mental function, accompanied by environmental adaptation and behavioural deterioration. Patient files of 87 children with intellectual disability were evaluated in this study. After clinical exclusion criterias, clinical exome sequencing was performed for 25 of 87 intellectual disability cases with a massively parallel targeted sequencing method. Seventeen variants in the genes MBOAT7, KDM5C, TUBB3, MAN1B1, GFAP, CACNA1A, BCOR, LMNA, LBR, ALS2, ENPP1, UBE3A, TRAPPC9, HSPG2, AFF2, NLGN4, and SOX10 were identified in 14 of 25 patients (56%). Seven of the 17 variants (41.1%) were novel in the genes KDM5C, BCOR, UBE3A, TRAPPC9, AFF2, NLGN4, and SOX10. Seven cases (7/25, 28%) had a definite diagnosis of intellectual disability with their pathogenic variants. The high rate of variant detection (56%) in the current study shows that multiple gene analysis plays an essential role in diagnosing the uncertain etiology of intellectual disability. This study also presents seven novel variants, which are first reported.Öğe Current Pattern of Psychiatric Comorbidity and Psychotropic Drug Prescription in Child and Adolescent Patients(Mdpi, 2019) Altay, Menguhan Araz; Bozatli, Leyla; Sipka, Begilm Demirci; Gorker, IsikBackground: In recent years, patterns of the use of psychotropic drugs vary with increasing rates of psychiatric presentation and diagnosis in children and adolescents. Purpose: In this study, we aimed to investigate distributions of current psychiatric symptoms and diagnosis, patterns of the use of psychotropic drugs, and differences according to age and gender in patients presented to a child and adolescent outpatient clinic. Methods: All patients aged between 0 and 18 years presenting to a child and adolescent psychiatry outpatient clinic between November 1, 2017 and November 1, 2018 were included in the study. Files of all patients were examined in detail, and patients' demographic characteristics, symptoms, psychiatric diagnoses established according to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), psychotropic drugs initiated, and side effect profiles were recorded. Psychiatric symptoms and diagnostic features of the patients were determined, and the differences were investigated according to gender. Clinical characteristics were compared between diagnosed and undiagnosed patients, and between patients with and without drug initiation. Results: Of the 2066 patients, 1298 (62.8%) were male and the mean age was 10.14 +/- 4.42 years. The most common symptoms were hyperactivity (23.8%) and inattention (21.6%) in males, inattention (15.1%) and irritability (14.2%) in females, and 79% of the patients received one or more psychiatric diagnoses. The most common psychiatric diagnoses in both genders were attention-deficit hyperactivity disorder (ADHD), specific learning disorder (SLD), and conduct disorder, respectively. Of the patients who received a psychiatric diagnosis, 61.8% were using psychotropic drugs, with the majority of them (71.3%) receiving monotherapy. The most frequently initiated drugs included psychostimulants, antipsychotics, and antidepressants, with 28.7% of the drug user patients receiving multiple drug therapy. Conclusion: Our study indicates that rate of presentation to child and adolescent psychiatry outpatient clinics is increasing, and rates of diagnosis and initiation of psychiatry drugs are high among the presented children. The prevalence of ADHD shows an increase in males and females in our country, and psychiatric polypharmacy has reached significant rates.Öğe Disturbed eating behavior and obesity in drug naive children diagnosed with attention deficit hyperactivity disorder(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2019) Aykutlu, Hasan Cem; Gorker, IsikObjective: In recent studies, attention deficit hyperactivity disorder (ADHD) was found to be linked with disturbed eating behavior and obesity. However, more studies needed to assess this relationship in pediatric age group. Therefore, eating behavior, dietary habits and obesity prevalence were evaluated in children who were newly diagnosed with ADHD. Methods: Eighty-six children with ADHD between the ages of 6 and 9 without medical treatment and chronic medical disease were included in the study group. 86 age and sex matched children without chronic medical and psychiatric disease were obtained as the control group. Sociodemographic Data Form, Children's Eating Behavior Questionnaire (CEBQ), the Turgay DSM-IV Based Disruptive Behavior Disorders Child and Adolescent Rating and Screening Scale (T-DSM-IV-S) and Schedule for Affective Disorders and Schizophrenia for School Age Children were applied to all cases. Weight and height of all cases were measured. Weight and height z scores, body mass index percentiles were calculated. Results: CEBQ desire to drink subscale scores were found significantly higher in ADHD group than controls. CEBQ food responsiveness, emotional overeating and desire to drink subscale scores were found as positively correlated with T-DSM-IV-S ADHD total scores in ADHD group. It was found that children with ADHD eat more often, prefer to consume less water than controls. Higher rates of obesity and overweight, lower rates of underweight were found statistically significant in ADHD group. Discussion: Our findings provide evidence that children who are newly diagnosed with ADHD could have impaired eating behaviors, high rates of obesity and overweight. Therefore, it is important to evaluate growth measures and dietary habits in this population.Öğe Drug-refractory irritability and related factors in autistic children(Taylor & Francis Ltd, 2024) Aykutlu, Hasan C.; Bozatli, Leyla; Gorker, Isik; Okyar, Esra; Uzun-Cicek, Ayla; Ucuz, Ilknur; Dogru, HicranObjectivesAutistic children frequently exhibit irritability, which can manifest as aggression, self-injurious behaviour, and severe tantrums, leading to significant impairments. Two atypical antipsychotics have been licensed by the Food and Drug Administration for the treatment of irritability in autistic children, although a significant percentage of these children do not respond to this treatment. This study aimed to determine the frequency of drug refractory irritability (DRI) and identify the risk factors in a large clinical sample of autistic children.MethodsThe medical records of 1279 children aged 2-18 years diagnosed with autism and undergoing clinical follow-up were retrospectively analysed. Socioeconomic and clinical characteristics, co-occurring psychiatric disorders and physical conditions were recorded.Results55% of the sample used antipsychotics to treat irritability, and 8.2% met the DRI criteria. Older age, severe support requirement for autism, language impairment, anxiety disorders, sleep difficulties, gastrointestinal system, and dental problems were found to significantly increase the risk of DRI.ConclusionOur findings indicate that a significant proportion of the clinical sample of autistic children had DRI. The physical, psychiatric, and environmental risk factors identified in our study also highlight heterogeneity in the etiology of DRI. Further research on DRI is needed to develop treatment and prevention strategies.Öğe Effect of neonatal resuscitation courses on long-term neurodevelopmental outcomes of newborn infants with perinatal asphyxia(Wiley-Blackwell, 2012) Duran, Ridvan; Gorker, Isik; Kucukugurluoglu, Yasemin; Ciftdemir, Nukhet Aladag; Ozbek, Ulfet Vatansever; Acunas, BetulBackground: In previous studies, it has been demonstrated that Neonatal Resuscitation Program (NRP) courses improve the early outcomes of infants with perinatal asphyxia, but there has been no evidence to demonstrate the effect of NRP on long-term outcomes of perinatal asphyxia. The goal of the present study was to determine the effect of NRP courses on the long-term neurodevelopmental outcome of perinatal asphyxia. Methods: This prospective study included infants referred to the Neonatal Unit during the years 2003-2005. Those patients who were referred before NRP courses (pretraining period) were designated as group 1, those who were referred after the first NRP course (transition period) as group 2, and those who were referred after the second NRP course (post-training period) as group 3. Neurodevelopmental outcomes were assessed and compared at 4-6 years of age. Results: The study involved 40 patients: 23 in group 1, nine in group 2 and eight in group 3. The number of patients who had been diagnosed with cerebral palsy was 13 in group 1, two in group 2, and one in group 3, which was a significant decrease. The number of patients with seizures and electroencephalography abnormality was 12 and 14 in group 1, three and two in group 2, and one and one in group 3, respectively, which was also a significant decrease. Conclusions: NRP courses have positive effects on short-term as well as long-term neurodevelopmental outcomes of infants with perinatal asphyxia. Further studies are required to determine the effects of NRP courses on minor deficits, such as cognitive and behavioral disturbances.Öğe Evaluation of psychiatric characteristics in children of parents with multiple sclerosis(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2020) Araz Altay, Menguhan; Gorker, Isik; Guler, Sibel; Demirci Sipka, Begum; Atas, TugceObjective: This study aims to investigate the psychiatric disorders in children with parental multiple sclerosis (MS) and to research the differences between without parental chronic disease. Methods: The children of the parents with MS diagnosis in the neurology department and the children of parents without chronic medical and psychiatric diseases were included in the study. Kiddie Schedule for Affective Disorders and Schizophrenia for School Aged Children Present and Lifetime Version (K-SADS-PL) was applied to the children. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinical Version (SCID-I-CV) was applied to parents with MS. Psychiatric characteristics of the parents and children were determined. The accompanying psychiatric disorders in children and adolescents with paternal MS and the clinical features affecting these disorders were analyzed. Results: Fifty children and adolescents with parental MS were included in the study group and 75 children and adolescents without a chronic disease in the parents were included in the control group. The mean age of children in the study group was 12.7 +/- 2.9 years and 58% were girls. 52% of the parents with MS were diagnosed with a psychiatric disorder. As a result of the evaluation, 54% of the children with parental MS were diagnosed with psychiatric disorder. The most common psychiatric diagnoses were anxiety disorders (30%), attention deficit and hyperactivity disorder (ADHD) (22%), and tic disorders (16%), respectively. The Expanded Disability Status Scale scores of the parents of children with psychiatric diagnoses were significantly higher than those of the children with no diagnosis. Conclusion: Children of MS patients have a high rate of psychiatric disorder. As the severity of MS increases, it is more common for children to be affected psychosocially. Children with parental MS should be follow-up for psychiatric disorders, especially for anxiety disorders and ADHD.Öğe Examining the autistic traits in children and adolescents diagnosed with attention-deficit hyperactivity disorder and their parents(Bmc, 2020) Okyar, Esra; Gorker, IsikBackgroundAttention-Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are two of the most frequently-observed neurodevelopmental disorders. Autistic traits are detected frequently in children who have ADHD. This study aimed to examine autism symptoms in children diagnosed with ADHD and their parents; and also, to investigate parental risk factors that increase autistic traits in children. Besides the risk factors related to pregnancy, birth and developmental history were examined.MethodsTwo groups were created consisting of 66 children diagnosed with ADHD and 33 children not diagnosed with ADHD and their parents. Autism symptoms were screened with the Autism Behavior Checklist (ABC) in children, and Autism Spectrum Quotient (AQ) in parents. Also, Adult ADD/ADHD DSM-IV Based Diagnostic Screening and Rating Scale and Wender Utah Rating Scale (WURS) were used to determine ADHD symptoms in parents.ResultsIt was determined that there were more autism symptoms in children who were diagnosed with ADHD than in the control group without ADHD. There were more autistic symptoms in boys and the presence of Oppositional Defiant Disorder (ODD). Although there were more ADHD symptoms in the parents of children diagnosed with ADHD, it was determined that they did not differ from parents in the control group in terms of autism symptoms. It was also determined that maternal and paternal ADHD symptoms were predictive for autism symptoms in children. It was also shown that maternal smoking during pregnancy is associated with more autistic traits.ConclusionASD and ADHD show high levels of comorbidity. The etiology remains unclear. Both ADHD and ASD show strong hereditary transition. We found that maternal and paternal ADHD symptoms predict autism symptoms in children with ADHD. However, more studies are needed to reveal the etiology.Öğe How Did the Pandemic Affect Autistic Children and Their Families? Challenges and Psychosocial Impacts(Galenos Publ House, 2023) Aykutlu, Hasan Cem; Guneydas Yildirim, Burcu; Bozatli, Leyla; Kose, Ekin Beyza; Gorker, IsikAim: Children with autism spectrum disorder (ASD) are especially vulnerable to the pandemic due to their need for routine and difficulty in adapting to change. The aim of this study was to evaluate the psychosocial impact of the Coronavirus disease-2019 (COVID-19) pandemic on children diagnosed with ASD and their families and the challenges they faced during this period. Materials and Methods: We surveyed 85 parents of children with ASD aged 3-18 years, who were followed up in our clinic between the years of 2020 and 2021. We assessed ASD families' pandemic impact with the Child and Adolescent Reactions to Stressful Situations-Autism Family Adaptation and Resilience items. Parents answered the questionnaire online or by phone. Results: The mean age of the children was 10.3 +/- 4.1 years, 65 were boys and 20 were girls. 10.6% of the families had a medical emergency during the pandemic. The most common behavioral problems were anger, difficulty in concentrating, and hyperactivity. 37.6% of the children could not receive educational support, 74.1% could not receive treatment, 31.1% had difficulty in reaching a doctor, and 7.8% had difficulty in affording treatment. Furthermore, 33% of the children spent more than 4 hours a day on screens. 61.2% of parents rated the pandemic quarantine process as more difficult than before. Conclusion: The pandemic disrupted the daily routines, special education, rehabilitation, and health care services of children with ASD. It also increased their behavioral problems. Therefore, recognizing and addressing the psychological needs of children with special needs, such as ASD, will be an important part of the response to future disasters.Öğe Improvement of stuttering with use of methylphenidate in a child who was diagnosed with concomitant stuttering and ADHD(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2016) Bozatli, Leyla; Berberoglu, Kivan Kudret; Ceylan, Cansin; Gorker, IsikStuttering is a psychological, neurological and neurophysiological rhythmic disorder in an understandable speech that is characterized by hesitation in speech flow, standstill with repeating a word or a sound, extension of a sound. Etiology of stuttering is not exactly known. In this case presentation, it is aimed to discuss the disappearance of stuttering in an 11 year old child who was diagnosed with stuttering and ADHD after treating with methylphenidate extended release.Öğe Investigation of Copy Number Variation by arrayCGH in Turkish Children and Adolescents Diagnosed with Autism Spectrum Disorders(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2018) Gorker, Isik; Gurkan, Hakan; Ulusal, Selma; Atli, Engin; Ayaz, Guclu; Ceylan, Cansin; Tozkir, HilmiAim: The development of whole-genome screening methodologies for the detection of copy number variations (CNVs), such as array-based comparative genomic hybridization (aCHG), provides a much higher resolution than karyotyping leading to the identification of novel microdeletion and microduptication syndromes often associated with an autism spectrum disease (ASD) phenotype. The aim of the study was to determine CNVs of patients with ASD by using array-based comparative genomic hybridization. Methods: Fifty-three patients diagnosed with ASD between 20.01.2014 and 14.01.2015 were included in the study. Chromosome analysis of the patients was performed from peripheral blood cultures and analysed as normal. All patients were evaluated with P064C1 and P096A2 MLPA probes in terms of 16 mental retardation related syndromes. For aCGH method, SurePrint G3 Human microarrays 8x60K were used with genomic DNA isolated from peripheral blood. Results According to results of 53 patients who were included in and performed with arrayCGH, 8 (15%) patients had CNVs classified as pathogenic or variant of unknown significance (VOUS) in the study. We detected a pathogenic NRXN1 gene partial CNV deletion (2p16.3) in two patients. Also we identified a 900 kb duplication of 4p15.31 including SLIT2 gene, and a 245 kb duplication of 15q11.2 including PWRN1 gene in one patient. Our other findings are considered to be a variant of unknown significance (VOUS). Conclusion: The results of the study support the literature knowledge, where the copy number variations that cannot be detected with conventional cytogenetics methods in terms of size may happen in patients with ASD.Öğe Investigation the Relationship of Autism Spectrum Disorder and FOXP2, GRIN2B, KATNAL2, GABRA4 Genes(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2021) Yalcintepe, Sinem; Gorker, Isik; Demir, Selma; Atli, Emine Ikbal; Atli, Engin; Tozkir, Hilmi; Sut, NecdetIntroduction: Autism spectrum disorder is a genetically and phenotypically heterogeneous group. Genetic studies carried out to date have suggested that both common and rare genetic variants play a role in the etiology of this disorder. In our study, we aimed to investigate the effect of FOXP2, GRIN2B, KATNAL2 and GABRA4 gene variants in the pathogenesis of autism spectrum disorder. Method: In our prospectively planned study, all exons and exon-intron junctions of FOXP2, GRIN2B, KATNAL2 and GABRA4 genes were screened by next generation sequencing analysis in 96 patients who diagnosed with autism spectrum disorder. Results: In our study, the average age was 10.1 and the male/female ratio was 75/21. Pathogenic or likely pathogenic variants were not detected in FOXP2, GRIN2B, KATNAL2 and GABRA4 genes, however, 69 intronic variants of unknown clinical significance were detected in 50 cases (52%). Among those, 26 were in the GABRA4 gene, 22 in the FOXP2 gene, 13 in the KATNAL2 gene, and 8 in the GRIN2B gene. Twenty three of these 69 variants were novel that were not previously reported in the literature. Conclusion: In our study, we could not identify a relationship between the autism spectrum disorder and FOXP2, GRIN28, KATNAL2 and GABRA4 genes. Identifying genetic risk factors that play a role in the etiopathogenesis of autism spectrum disorder will contribute significantly to understanding the molecular mechanisms of the disease and the development of new treatment strategies. In this context, comprehensive molecular genetic studies such as whole exome or whole genome sequencing are required with higher number of cases in different populations.Öğe Maternal anxiety and internet-based food elimination in suspected food allergy(Wiley, 2019) Beken, Burcin; Celik, Velat; Ozdemir, Pinar Gokmirza; Sut, Necdet; Gorker, Isik; Yazicioglu, MehtapBackground Food allergy is associated with stress, anxiety, and impairment in quality of life in both children and families. This study aimed to assess the anxiety of mothers in the case of suspected food allergy in their children and the influence of Internet usage on their levels of anxiety and food elimination. Methods Ninety-two patients aged 0-2 years presented at a pediatric allergy department following either a physicians' presumptive diagnosis or family's suspicion of food allergy (Group 1) and 99 healthy controls (Group 2) were evaluated. The clinical diagnosis of food allergy was confirmed or excluded by oral food challenge (OFC). The validated Turkish version of Spielberger State-Trait Anxiety Inventory (STAI) was applied to the mothers of both groups on admission and to Group 1 3 months after OFC. Results The state and trait anxiety (STAI-S and STAI-T) scores were significantly higher in Group 1 than Group 2 (P < 0.001, z = 5.410, and P = 0.021, z = 2.304, respectively). Seventy-nine mothers (85.9%) had been eliminating foods on admission. Thirty-seven (40.2%) mothers had eliminated foods on their own. The performance of food allergy-related Web searches was significantly higher among mothers who eliminated foods by themselves than those who did not (P = 0.004, chi(2) = 8.391, df = 1). The second STAI-S score was significantly lower among mothers whose children's food allergy diagnosis was excluded than confirmed (effect size = 1.06 (95% CI: 0.56-1.57), P = 0.001, z = 3.442). Conclusion It is important to make a correct food allergy diagnosis with a detailed allergy work-up, including OFC, to avoid anxiety and not cause unnecessary food elimination.Öğe Neurodevelopmental and psychiatric assessments at corrected age of 1-3 years in very preterm infants(Turkish Pediatrics Assoc, 2011) Gorker, Isik; Vatansever, Ulfet; Acunas, BetulAim: To assess the neurodevelopmental and psychiatric outcomes of very preterm vs preterm infants at 1-3 years of corrected age. Material and Method: Between years 2005-2008, premature infants followed-up in the NICU designated as Group 1 (<32 wks;n=36) were evaluated in comparison to Group 2 (33-37wks; n=56) with the approval of Ethics Committee (TUTFEK 2008/083) in terms of neurodevelopmental and psychiatric development by using Denver developmental screening test, the brief infant toddler social emotional assessment-childcare provider version. Mothers' psychiatric symptoms were assessed by the brief symptom inventory. Socioeconomic status was determined by using SES scale. t-test or Mann-Whitney U tests, chi-square and Spearman tests were used for statistical analysis. Results: In Group 1, paternal education level and psychodevelopmental score was lower than group 2, abnormal outcome in Denver developmental test was more frequent. Psychiatric problem score was higher in boys, whereas psychodevelopmental score was higher in girls. Psychosocial developmental score was lower in those infants with intraventricular hemorrhage and this score showed positive correlation with Denver developmental test results. There was no difference between the two groups in terms of brief symptom inventory. Conclusions: Although very preterm infants more frequently showed abnormal neuropsychological development, they were not significantly different with regard to psychiatric problems. Girls were more advantegous than boys in terms of psychodevelopment. We conclude that these findings should be validated by larger and further studies. (Turk Arch Ped 2011; 46: 280-5)Öğe Öğe Obsessive compulsive symptoms in mothers of children with atopic dermatitis(Termedia Publishing House Ltd, 2023) Celik, Velat; Beken, Burcin; Gorker, Isik; Ozdemir, Pinar Gokmirza; Sut, Necdet; Yazicioglu, MehtapIntroduction: Maternal stress, depression and anxiety are associated with atopic dermatitis (AD) in offspring. How- ever, the relationship between maternal obsessive compulsive symptoms (OCS) and AD in their children is unclear.Aim: To investigate whether maternal OCS are associated with AD in offspring.Material and methods: A total of 75 children with AD diagnosed by the paediatric allergist and 76 healthy children and their mothers were included in the study. A Turkish version of the Maudsley Obsessive Compulsive Inventory (MOCI-T) was used to assess OCS of mothers in both groups.Results: Total MOCI-T score and slowness, doubt, and rumination subscale scores were higher in the AD group than in the healthy group (p = 0.007, p = 0.001, p = 0.012 and p = 0.011, respectively) but washing/cleaning and checking subscale scores did not reach a statistically significant difference (p = 0.203 and p = 0.053, respectively). There was no correlation between SCORing Atopic Dermatitis (SCORAD) and MOCI-T/subscales scores.Conclusions: Our study provides evidence for associations between maternal OCS and infantile AD. The findings support recommendations for psychosocial support of mothers of children with AD.
