Drug-refractory irritability and related factors in autistic children
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
ObjectivesAutistic children frequently exhibit irritability, which can manifest as aggression, self-injurious behaviour, and severe tantrums, leading to significant impairments. Two atypical antipsychotics have been licensed by the Food and Drug Administration for the treatment of irritability in autistic children, although a significant percentage of these children do not respond to this treatment. This study aimed to determine the frequency of drug refractory irritability (DRI) and identify the risk factors in a large clinical sample of autistic children.MethodsThe medical records of 1279 children aged 2-18 years diagnosed with autism and undergoing clinical follow-up were retrospectively analysed. Socioeconomic and clinical characteristics, co-occurring psychiatric disorders and physical conditions were recorded.Results55% of the sample used antipsychotics to treat irritability, and 8.2% met the DRI criteria. Older age, severe support requirement for autism, language impairment, anxiety disorders, sleep difficulties, gastrointestinal system, and dental problems were found to significantly increase the risk of DRI.ConclusionOur findings indicate that a significant proportion of the clinical sample of autistic children had DRI. The physical, psychiatric, and environmental risk factors identified in our study also highlight heterogeneity in the etiology of DRI. Further research on DRI is needed to develop treatment and prevention strategies.
Açıklama
Anahtar Kelimeler
Autism Spectrum Disorders, Irritability, Challenging Behaviour, Drug Refractory, Children, Self-Injurious Behaviors, Spectrum Disorder, Challenging Behaviors, Gastrointestinal Symptoms, Adolescents, Aggression, Aripiprazole, Individuals, Risperidone, Severity
Kaynak
International Journal Of Developmental Disabilities
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
