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Öğe Burned-out tumor of the testis: Case report(2008) Kaplan M.; Karagöl H.; Altaner Ş.; Aktoz T.; Çalo?lu M.; Inci O.Introduction: Burned-out testicular tumor is a rare entity. The term "burned-out" tumor of the testis describes a spontaneously and completely regressed testicular tumor which presents by its metastases to retroperitoneum, mediastinum, lymph nodes such as supraclavicular, cervical and axillary. This condition is different and less common from the primary extragonadal germ cell tumors. Many pathologists are not familiar with the findings that support a diagnosis of "burned-out" primary in a patient with metastatic germ cell tumor. We report 2 cases of burned-out testicular tumors to illustrate the clinical, radiological and histopathological features. Burned-out testicular tumor must be considered in a patient with retroperitoneal lymph node involvement and histology of germ-cell tumor in the absence of palpable testicular tumor. Metastases should be treated according to the histology and clinical stage of the tumor. Radical orchiectomy must be performed because of the high rate of persistent testicular tumor.Öğe A case of isolated bilateral renal metastases from carcinoma of the lung(2004) Uzal M.C.; Koçak Z.; Uygun K.; Altaner Ş.; Gözen S.; Ünlü E.Renal metastases in patients with history of cancer may mimic primary renal tumors. When the kidneys are the only known pathological sites in patients with locally controlled disease, the differentiation of renal metastases and primary renal cell carcinoma may be very difficult clinically and radiologically. A case of lung carcinoma developing isolated bilateral renal metastases that was recognized ante mortem is described.Öğe Detection of protein p53 in gastric carcinomas: An immunohistochemical study of 50 cases(2000) Özyilmaz F.; Altaner Ş.; Kutlu A.K.Methods: p53 protein which is a tumor supressor gen production was investigated in 50 primary gastric carcinomas by immunohistochemical study. Results: p53 immunreactivity was detected in 66 per cent (n=33) of all cases. Abnormal p53 expression were found in 17 of the 20 (85 %) intestinal carcinomas, in 13 of the 22 (59 %) diffuse carcinomas and in 3 of the 8 (37.5 %) undifferantiated gastric carcinomas. Positive staining was not seen in normal epithelium and in epithelium with intestinal metaplasia which are near to the tumoral tissue. Ratio of positive immunostaining with p53 was higher in cases older than 50 years, in intestinal type tumors and also in tumors showing expanding type pattern and without having perineural invasion. No relation was found between p53 staining and parameters such as nuclear grade, invasion depth, lymph node invasion and sex. Conclusions: The results of the present immunohistochemical study of p53 accumulation in gastric carcinomas suggest that gene alterations of p53 are not rare in gastric carcinomas and may participate in the carcinogenesis of intestinal type carcinomas of the stomach.Öğe The importance of using PET/CT investigation in case of recurrence in an ovarian cancer case with lymph node metastasis without any lesions that can be scanned via conventional methods(2008) Tanriverdi Ö.; Uzuno?lu S.; Karagöl H.; Cicin I.; Coşar Alas R.; Tokatli F.; Altaner Ş.Although lymph node involvement is common in ovarian cancer, axillary and supraclavicular lymph node involvement is quite rare. In the 55-year-old patient without any lesions that are scannable via conventional methods, in which increase of CA-125 level was detected during follow-up, recurrence was detected via combined positron emission tomography and computed tomography investigation. This case recurring with intraabdominal and supraclavicular and axillary lymph node (which are rare regions of involvement) metastasis has been discussed with literature information. In this article, the importance of combined positron emission tomography and computed tomography investigation in patients with suspected recurrence in whom no tumor detectable via conventional methods has been identified was highlighted.Öğe Isolated extramedullary plasmacytoma of the true vocal cord: A case report and review of the literature(2006) Tokatli F.; Tunçbilek N.; Altaner Ş.; Koçak Z.; Uzal C.; Denizli B.; Taş A.Extramedullary plasmacytoma (EMP) is an uncommon neoplastic disorder arising from B-cell series lymphocytes and comprises 3% of plasma cell neoplasms and 0.1% of laryngeal carcinomas. Isolated EMP of the true vocal cord is an extremely rare lesion. Only 9 cases have been reported in the English medical literature. We report a case of isolated EMP of the right true vocal cord in a 55-year-old male with a 10-year history of intermittent hoarseness. Although this appears to be an isolated case, EMP of the true vocal cord must be included in the differential diagnosis in patients with history of longstanding hoarseness.Öğe The prescence of Helicobacter pylori in Meckel's diverticulum of children(2004) Altaner Ş.; Inan M.; Güreşçi S.; Öz Puyan F.; Do?anay L.Aim: Meckel's diverticulum is the most common congenital abnormality of the gastrointestinal tract. Gastric mucosa is usually present in Meckel's diverticulum. Helicobacter pylori (H. pylori) can also be detected in ectopic or heterotopic gastric mucosa. The aim of this study is to investigate Helicobacter pylori colonization in heterotopic gastric mucosa of Meckel's diverticulum in children. Method: A total of 18 cases who had undergone diverticulectomy at childhood were included in the study to search for the presence of H. pylori in Meckel's diverticulum. The paraffin blocks of all the patients were evaluated and stained with Warthin-Starry silver stain. Result: There were 12 male and 6 female patients with a mean age of 4.7. The most common symptom was abdominal pain (12/18). 10 out of 18 Meckel's diverticulum had heterotopic gastric mucosa. In 6 patients abdominal pain and in 4 of 10 patients rectal bleeding was the main symptom. H. pylori was recognized in 3 of 10 cases which contained gastric mucosa. 2 of these 3 patients who were infected with H. pylori had presented with abdominal pain and 1 patient with rectal bleeding. Conclusion: According to our results we suggest that H. pylori doesn't play a role in the development of ulceration and bleeding in Meckel's diverticulum with heterotopic gastric mucosa.Öğe Prevention of radiation-induced liver and kidney toxicity: A role for amifostine(2007) U?uzalp-Kaldir M.; Yürüt-Çalo?lu V.; Coşar-Alas R.; Çermik T.F.; Altaner Ş.; Eskiocak S.; Saynak M.Objectives: To investigate the protective effect of amifostine against radiation induced liver and kidney injury of rats, using scintigraphic and histopathologic parameters. Methods: Female Wistar Albino rats were randomly allocated to 3 groups: control, radiotherapy alone (RT), and amifostine+RT (n=10). Single-dose of 600 cGy X-ray was performed with a single field compromised liver and right kidney. Amifostine was administered intraperitoneally at a dose of 400 mg/kg, 30 minutes before irradiation. Scintigraphic evaluation was performed before irradiation and the end of the study at 6 nd month. Histopathologic examinations were performed post mortem. Results: A clear protective effect of amifostine against radiation-induced late damage in liver and kidney was found with scintigraphic evaluation. In addition, amifostine reduced the decrease of histopathologic changes for both of the tissues. Conclusion: The results showed that amifostine significantly reduced radiation-induced liver and kidney toxicity and therefore warrant additional study in a clinically relevant fractionated model.
