Detection of protein p53 in gastric carcinomas: An immunohistochemical study of 50 cases
Küçük Resim Yok
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Methods: p53 protein which is a tumor supressor gen production was investigated in 50 primary gastric carcinomas by immunohistochemical study. Results: p53 immunreactivity was detected in 66 per cent (n=33) of all cases. Abnormal p53 expression were found in 17 of the 20 (85 %) intestinal carcinomas, in 13 of the 22 (59 %) diffuse carcinomas and in 3 of the 8 (37.5 %) undifferantiated gastric carcinomas. Positive staining was not seen in normal epithelium and in epithelium with intestinal metaplasia which are near to the tumoral tissue. Ratio of positive immunostaining with p53 was higher in cases older than 50 years, in intestinal type tumors and also in tumors showing expanding type pattern and without having perineural invasion. No relation was found between p53 staining and parameters such as nuclear grade, invasion depth, lymph node invasion and sex. Conclusions: The results of the present immunohistochemical study of p53 accumulation in gastric carcinomas suggest that gene alterations of p53 are not rare in gastric carcinomas and may participate in the carcinogenesis of intestinal type carcinomas of the stomach.
Açıklama
Anahtar Kelimeler
Gastric Carcinoma; Immunohistochemistry; P53, Protein P53; Adult; Article; Cancer Grading; Cancer Invasion; Clinical Article; Female; Gene Mutation; Human; Human Tissue; Immunohistochemistry; Immunoreactivity; Intestine Carcinoma; Male; Protein Analysis; Protein Expression; Stomach Carcinogenesis; Stomach Carcinoma; Tumor Suppressor Gene; Undifferentiated Carcinoma
Kaynak
Turkish Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
11
Sayı
4
