Prevention of radiation-induced liver and kidney toxicity: A role for amifostine
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: To investigate the protective effect of amifostine against radiation induced liver and kidney injury of rats, using scintigraphic and histopathologic parameters. Methods: Female Wistar Albino rats were randomly allocated to 3 groups: control, radiotherapy alone (RT), and amifostine+RT (n=10). Single-dose of 600 cGy X-ray was performed with a single field compromised liver and right kidney. Amifostine was administered intraperitoneally at a dose of 400 mg/kg, 30 minutes before irradiation. Scintigraphic evaluation was performed before irradiation and the end of the study at 6 nd month. Histopathologic examinations were performed post mortem. Results: A clear protective effect of amifostine against radiation-induced late damage in liver and kidney was found with scintigraphic evaluation. In addition, amifostine reduced the decrease of histopathologic changes for both of the tissues. Conclusion: The results showed that amifostine significantly reduced radiation-induced liver and kidney toxicity and therefore warrant additional study in a clinically relevant fractionated model.
Açıklama
Anahtar Kelimeler
Amifostine; Kidney/Radiation Effects; Liver/Radiation Effects; Radiotherapy/Yan Etki; Risk Factors; Toxicity, Amifostine; Animal Experiment; Animal Model; Article; Controlled Study; Female; Kidney Injury; Kidney Scintiscanning; Liver Injury; Liver Scintiscanning; Nonhuman; Radiation Dose; Radiation Injury; Radiation Protection; Radiotherapy; Rat; Wistar Rat
Kaynak
Turk Onkoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
22
Sayı
3
