Reduction of dependence to cannabinoids by GLT-1 activating property of the beta-lactam antibiotic

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T11:19:59Z
dc.date.available2024-06-12T11:19:59Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSince GLT-1 transporters play the key role in terminating synaptic transmission of glutamate, drugs stimulating GLT-1 expression are expected to offer neuroprotection. Of these, beta-lactam antibiotics have been suggested to contribute to various central nervous system disorders, including development of tolerance and dependence to opioids, and tolerance to cannabinoids. Opioids and cannabinoids share many pharmacological properties. All together, it can be hypothesized that beta-lactam antibiotics may reduce the development of dependence to cannabinoids through activating GLT-1. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.mehy.2012.11.040
dc.identifier.endpage248en_US
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.issue3en_US
dc.identifier.pmid23253111en_US
dc.identifier.scopus2-s2.0-84874545248en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2012.11.040
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25411
dc.identifier.volume80en_US
dc.identifier.wosWOS:000315834400008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpinal 5-Ht7en_US
dc.subjectAnalgesic Toleranceen_US
dc.subjectPhysical-Dependenceen_US
dc.subjectMorphine-Toleranceen_US
dc.subjectOpioid Toleranceen_US
dc.subjectNitric-Oxideen_US
dc.subjectExpressionen_US
dc.subjectAntinociceptionen_US
dc.subjectReceptorsen_US
dc.subjectTransportersen_US
dc.titleReduction of dependence to cannabinoids by GLT-1 activating property of the beta-lactam antibioticen_US
dc.typeArticleen_US

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