Reduction of dependence to cannabinoids by GLT-1 activating property of the beta-lactam antibiotic
Küçük Resim Yok
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Churchill Livingstone
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Since GLT-1 transporters play the key role in terminating synaptic transmission of glutamate, drugs stimulating GLT-1 expression are expected to offer neuroprotection. Of these, beta-lactam antibiotics have been suggested to contribute to various central nervous system disorders, including development of tolerance and dependence to opioids, and tolerance to cannabinoids. Opioids and cannabinoids share many pharmacological properties. All together, it can be hypothesized that beta-lactam antibiotics may reduce the development of dependence to cannabinoids through activating GLT-1. (C) 2012 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Spinal 5-Ht7, Analgesic Tolerance, Physical-Dependence, Morphine-Tolerance, Opioid Tolerance, Nitric-Oxide, Expression, Antinociception, Receptors, Transporters
Kaynak
Medical Hypotheses
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
80
Sayı
3
