Cannabinoid Receptors Are Not Involved in Antinociception Induced by Systemic Diclofenac in Mice

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dc.contributor.authorChatzisali, Beiza
dc.contributor.authorGaş, Tolga
dc.contributor.authorKılgın, Hilmi
dc.contributor.authorAydemir, Kübra Duvan
dc.contributor.authorErümit, Dilşat
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorUlugöl, Ahmet
dc.date.accessioned2021-11-20T10:26:57Z
dc.date.available2021-11-20T10:26:57Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Anabilim Dalıen_US
dc.description.abstractAims: It has been long suspected that the cannabinoid system participates in the antinociceptive effects of nonsteroidal anti-inflammatory drugs. We studied the possible effects of cannabinoid receptor antagonism on diclofenac-induced antinociceptionin the writhing test in mice. Methods: In our study, male BALB/c mice, weighing 20-30 g, were used. Writhing responses wereproduced by intraperitoneal injection of 0.6% acetic acid. Different doses of diclofenac (3, 10, 30 mg/kg, i.p.) were tested, thenthe influence of AM-251 (1 mg/kg, i.p.), a cannabinoid CB1 receptor antagonist and AM-630 (3 mg/kg, i.p.), a cannabinoidCB2 receptor antagonist on the antinociceptive effects of diclofenac was studied. Results: Diclofenac administration elicited asignificant, dose-dependent antinociceptive response; however, neither the cannabinoid CB1 receptor antagonist AM-251 northe cannabinoid CB2 receptor antagonist AM-630 had any influence on the antinociceptive effect of diclofenac. Conclusion:Iinhibition of cannabinoid receptors does not contribute to the antinociceptive action of systemic diclofenac. Further studiesare needed to explain the antinociceptive mechanism of diclofenac. Keywords: AM-251, AM-630, antinociception, cannabinoidreceptors, diclofenacen_US
dc.identifier.dergipark700217en_US
dc.identifier.endpage4en_US
dc.identifier.issn2148-4724
dc.identifier.issn2548-0030
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dergipark.org.tr/tr/pub/tmsj/issue/52947/700217
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/997061
dc.identifier.urihttps://hdl.handle.net/20.500.14551/6232
dc.identifier.volume7en_US
dc.language.isoenen_US
dc.publisherTrakya Üniversitesien_US
dc.relation.ispartofTurkish Medical Student Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAM-251en_US
dc.subjectAM-630en_US
dc.subjectantinociceptionen_US
dc.subjectcannabinoid receptorsen_US
dc.subjectdiclofenacen_US
dc.titleCannabinoid Receptors Are Not Involved in Antinociception Induced by Systemic Diclofenac in Miceen_US
dc.typeArticleen_US

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