Effects of polygeline and hydroxyethyl starch solutions on liver functions assessed with LIMON in hypovolemic patients

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dc.contributor.authorInal, Mehmet Turan
dc.contributor.authorMemis, Dilek
dc.contributor.authorKaramanlioglu, Beyhan
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:03:46Z
dc.date.available2024-06-12T11:03:46Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Hypovolemia is a common clinical entity in critical patients, and adequate volume replacement therapy seems to be essential for maintaining tissue perfusion. However, it is still uncertain which solution is most appropriate for fluid resuscitation. Objective: The aim of this study was to investigate the effects of fluid resuscitation with 3.5% polygeline versus 6% hydroxyethyl starch solutions on hemodynamic functions and liver functions assessed with a noninvasive liver function monitoring system (LIMON) in hypovolemic patients. Design: This study is a prospective randomized clinical trial. Measurements and Results: Thirty hypovolemic patients (intrathoracic blood volume index, <850mL/m(2)) were randomized into hydroxyethyl starch (mean molecular weight, 130 000 Da) and polygeline (mean molecular weight, 30 000 Da) groups (15 patients each). Indocyanine green plasma disappearance elimination (ICG-PDR) were conducted concurrently using LIMON. A dose of 0.3 mg/kg ICG was given through a cubital fossa vein as a bolus. For fluid resuscitation, 500 mL of colloid was given to the patients. Repeated hemodynamic and ICG-PDR measurements were done at baseline, after infusion, and then at 30 minutes after infusion. Results: Intrathoracic blood volume index and systolic, diastolic, and mean blood pressures increased significantly after infusion and remained elevated for 30 minutes after infusion, but there was no significant difference between the 2 groups. Indocyanine green plasma disappearance elimination values were similar in both groups with no significant difference between the two. Conclusion: Increasing intrathoracic blood volume index and hemodynamic variables by fluid loading is not associated with a significant change in ICG-PDR. (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipUniversity of Trakya [TUBAP 2008/70]en_US
dc.description.sponsorshipThis work was supported by the University of Trakya research grant no. TUBAP 2008/70.en_US
dc.identifier.doi10.1016/j.jcrc.2009.06.013
dc.identifier.issn0883-9441
dc.identifier.issn1557-8615
dc.identifier.issue2en_US
dc.identifier.pmid19682845en_US
dc.identifier.scopus2-s2.0-77953291665en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcrc.2009.06.013
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21785
dc.identifier.volume25en_US
dc.identifier.wosWOS:000283718600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Critical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIndocyanine Greenen_US
dc.subjectPlasma Disappearance Rateen_US
dc.subjectColloid Solutionsen_US
dc.subjectCritically-Ill Patientsen_US
dc.subjectPlasma Disappearance Rateen_US
dc.subjectIndocyanine Green Clearanceen_US
dc.subjectIntrathoracic Blood-Volumeen_US
dc.subjectSeptic Shocken_US
dc.subjectMechanical Ventilationen_US
dc.subjectRenal-Failureen_US
dc.subjectMicrocirculationen_US
dc.subjectSepsisen_US
dc.subjectHesen_US
dc.titleEffects of polygeline and hydroxyethyl starch solutions on liver functions assessed with LIMON in hypovolemic patientsen_US
dc.typeArticleen_US

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