Effects of polygeline and hydroxyethyl starch solutions on liver functions assessed with LIMON in hypovolemic patients
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Hypovolemia is a common clinical entity in critical patients, and adequate volume replacement therapy seems to be essential for maintaining tissue perfusion. However, it is still uncertain which solution is most appropriate for fluid resuscitation. Objective: The aim of this study was to investigate the effects of fluid resuscitation with 3.5% polygeline versus 6% hydroxyethyl starch solutions on hemodynamic functions and liver functions assessed with a noninvasive liver function monitoring system (LIMON) in hypovolemic patients. Design: This study is a prospective randomized clinical trial. Measurements and Results: Thirty hypovolemic patients (intrathoracic blood volume index, <850mL/m(2)) were randomized into hydroxyethyl starch (mean molecular weight, 130 000 Da) and polygeline (mean molecular weight, 30 000 Da) groups (15 patients each). Indocyanine green plasma disappearance elimination (ICG-PDR) were conducted concurrently using LIMON. A dose of 0.3 mg/kg ICG was given through a cubital fossa vein as a bolus. For fluid resuscitation, 500 mL of colloid was given to the patients. Repeated hemodynamic and ICG-PDR measurements were done at baseline, after infusion, and then at 30 minutes after infusion. Results: Intrathoracic blood volume index and systolic, diastolic, and mean blood pressures increased significantly after infusion and remained elevated for 30 minutes after infusion, but there was no significant difference between the 2 groups. Indocyanine green plasma disappearance elimination values were similar in both groups with no significant difference between the two. Conclusion: Increasing intrathoracic blood volume index and hemodynamic variables by fluid loading is not associated with a significant change in ICG-PDR. (C) 2010 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Indocyanine Green, Plasma Disappearance Rate, Colloid Solutions, Critically-Ill Patients, Plasma Disappearance Rate, Indocyanine Green Clearance, Intrathoracic Blood-Volume, Septic Shock, Mechanical Ventilation, Renal-Failure, Microcirculation, Sepsis, Hes
Kaynak
Journal Of Critical Care
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
25
Sayı
2
