Antioxidant effects of sulfur-containing amino acids

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dc.contributor.authorAtmaca, G
dc.date.accessioned2024-06-12T10:59:06Z
dc.date.available2024-06-12T10:59:06Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSulfur is an essential element for the entire biological kingdom because of its incorporation into amino acids, proteins and other biomolecules. Sulfur atoms are also important. in the iron-containing flavoenzymes. Unlike humans, plants can use inorganic sulfur to synthesize sulfur-containing amino acids. Therefore, plants are an important source of sulfur for humans. Sulfur-containing compounds are found in all body cells and are indispensable for life. Some of sulfur-containing antioxidant compounds are, cysteine, methionine, taurine, glutathione, lipoic acid, mercaptopropionylglycine, N-acetylcysteine, and the three major organosulfur compounds of garlic oil, diallylsulfide, diallyldisulfide and diallyltrisulfide. In a comparison of the structure-function relationship among these sulfur-containing antioxidant compounds, dihydrolipoic acid (the reduced form of LA) is the most effective antioxidant. Dihydrolipoic acid contains two sulfhydryl groups and can undergo further oxidation reaction to form lipoic acid. The antioxidative activities of sulfur-containing compounds follow a general trend, the more highly reduced forms are stronger antioxidants and the number of sulfur atoms determine, at least in part, their modulatory activites on the glutathione related antioxidant enzymes. In this article, the antioxidant effects and the antioxidative activities, of sulfur-containing amino acids, are reviewed. In addition, the general antioxidant effects and the structure-function relationship of some sulfur-containing compounds are also reviewed.en_US
dc.identifier.doi10.3349/ymj.2004.45.5.776
dc.identifier.endpage788en_US
dc.identifier.issn0513-5796
dc.identifier.issn1976-2437
dc.identifier.issue5en_US
dc.identifier.pmid15515186en_US
dc.identifier.scopus2-s2.0-9144267060en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage776en_US
dc.identifier.urihttps://doi.org/10.3349/ymj.2004.45.5.776
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20313
dc.identifier.volume45en_US
dc.identifier.wosWOS:000224899400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherYonsei Univ Coll Medicineen_US
dc.relation.ispartofYonsei Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCysteinen_US
dc.subjectMethionineen_US
dc.subjectTaurineen_US
dc.subjectLipoic Aciden_US
dc.subjectN-Acetylcysteineen_US
dc.subjectMercaptopropionylglycineen_US
dc.subjectAlpha-Lipoic Aciden_US
dc.subjectLipid-Peroxidationen_US
dc.subjectHypochlorous Aciden_US
dc.subjectN-Acetylcysteineen_US
dc.subjectOxidative Stressen_US
dc.subjectPeroxynitrite Reactionen_US
dc.subjectMethionine Residuesen_US
dc.subjectSuperoxide Anionen_US
dc.subjectFree-Radicalsen_US
dc.subjectRat-Liveren_US
dc.titleAntioxidant effects of sulfur-containing amino acidsen_US
dc.typeReview Articleen_US

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