Antioxidant effects of sulfur-containing amino acids
Küçük Resim Yok
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Yonsei Univ Coll Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Sulfur is an essential element for the entire biological kingdom because of its incorporation into amino acids, proteins and other biomolecules. Sulfur atoms are also important. in the iron-containing flavoenzymes. Unlike humans, plants can use inorganic sulfur to synthesize sulfur-containing amino acids. Therefore, plants are an important source of sulfur for humans. Sulfur-containing compounds are found in all body cells and are indispensable for life. Some of sulfur-containing antioxidant compounds are, cysteine, methionine, taurine, glutathione, lipoic acid, mercaptopropionylglycine, N-acetylcysteine, and the three major organosulfur compounds of garlic oil, diallylsulfide, diallyldisulfide and diallyltrisulfide. In a comparison of the structure-function relationship among these sulfur-containing antioxidant compounds, dihydrolipoic acid (the reduced form of LA) is the most effective antioxidant. Dihydrolipoic acid contains two sulfhydryl groups and can undergo further oxidation reaction to form lipoic acid. The antioxidative activities of sulfur-containing compounds follow a general trend, the more highly reduced forms are stronger antioxidants and the number of sulfur atoms determine, at least in part, their modulatory activites on the glutathione related antioxidant enzymes. In this article, the antioxidant effects and the antioxidative activities, of sulfur-containing amino acids, are reviewed. In addition, the general antioxidant effects and the structure-function relationship of some sulfur-containing compounds are also reviewed.
Açıklama
Anahtar Kelimeler
Cystein, Methionine, Taurine, Lipoic Acid, N-Acetylcysteine, Mercaptopropionylglycine, Alpha-Lipoic Acid, Lipid-Peroxidation, Hypochlorous Acid, N-Acetylcysteine, Oxidative Stress, Peroxynitrite Reaction, Methionine Residues, Superoxide Anion, Free-Radicals, Rat-Liver
Kaynak
Yonsei Medical Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
45
Sayı
5
