Depression, cytokines and immune system

Basit Öğe Kaydı
dc.authorscopusid6507003285
dc.authorscopusid7005359398
dc.contributor.authorTu?lu C.
dc.contributor.authorKara S.H.
dc.date.accessioned2024-06-12T10:28:21Z
dc.date.available2024-06-12T10:28:21Z
dc.date.issued2003
dc.description.abstractThere is strong evidence that the immune system and the central nervous system communicate bidirectionally via hormons, transmiters and peptides. Multiple studies have well documented the potential effect of psychological stress and a major psychiatric disorder on the immune response and the immune mediated disease. The cytokines are a diverse group of proteins that may be regarded as the hormones of the immune system. It is known that cytokines are endocrinologically, electrophysiologically, and behaviorally active. Cytokines produced from peripheral leukocytes can pass the blood-brain barrier into the brain. Central and peripheral administration of cytokines influence fever, sleep and eating behavior, locomotor and exploratory behavior, and the mood states. There has been increasing evidence to suggest that immunological activation and hypersecretion of pro-inflammatory cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha may have a causal relationship with etiology of depression. Although the precise mechanism of antidepressants is uncertain, there is evidence that they can reduce the release of pro-inflammatory cytokines and other immunological parameters. Immune suppressive effects of antidepressants could be important for their mechanism of action. Consideration of inter-relationships between the immune-endocrine-neurotransmitter systems has been important in stimulating new concepts regarding both the biology of depression and the mechanism of action of antidepressants.en_US
dc.identifier.endpage150en_US
dc.identifier.issn1017-7833
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0142058179en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage142en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17200
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofKlinik Psikofarmakoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntidepressants; Cytokine; Depression; Immune Systemen_US
dc.subjectCytokine; Interleukin 1; Interleukin 6; Tumor Necrosis Factor Alpha; Blood Brain Barrier; Depression; Exploratory Behavior; Feeding Behavior; Fever; Human; Immune System; Locomotion; Mood; Review; Sleepen_US
dc.titleDepression, cytokines and immune systemen_US
dc.title.alternativeDepresyon, Sitokinler ve Ba?işiklik Sistemien_US
dc.typeReview Articleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu