Depression, cytokines and immune system
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
There is strong evidence that the immune system and the central nervous system communicate bidirectionally via hormons, transmiters and peptides. Multiple studies have well documented the potential effect of psychological stress and a major psychiatric disorder on the immune response and the immune mediated disease. The cytokines are a diverse group of proteins that may be regarded as the hormones of the immune system. It is known that cytokines are endocrinologically, electrophysiologically, and behaviorally active. Cytokines produced from peripheral leukocytes can pass the blood-brain barrier into the brain. Central and peripheral administration of cytokines influence fever, sleep and eating behavior, locomotor and exploratory behavior, and the mood states. There has been increasing evidence to suggest that immunological activation and hypersecretion of pro-inflammatory cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha may have a causal relationship with etiology of depression. Although the precise mechanism of antidepressants is uncertain, there is evidence that they can reduce the release of pro-inflammatory cytokines and other immunological parameters. Immune suppressive effects of antidepressants could be important for their mechanism of action. Consideration of inter-relationships between the immune-endocrine-neurotransmitter systems has been important in stimulating new concepts regarding both the biology of depression and the mechanism of action of antidepressants.
Açıklama
Anahtar Kelimeler
Antidepressants; Cytokine; Depression; Immune System, Cytokine; Interleukin 1; Interleukin 6; Tumor Necrosis Factor Alpha; Blood Brain Barrier; Depression; Exploratory Behavior; Feeding Behavior; Fever; Human; Immune System; Locomotion; Mood; Review; Sleep
Kaynak
Klinik Psikofarmakoloji Bulteni
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
13
Sayı
3
