Glucose-Induced Alteration of Accumulation of Organotechnetium Complexes Accumulation in Pgp-Negative Tumor-Bearing Mice

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.contributor.authorUstun, Funda
dc.contributor.authorDurmus-Altun, Gulay
dc.contributor.authorCukur, Ziya
dc.contributor.authorAltaner, Semsi
dc.contributor.authorBerkarda, Sakir
dc.date.accessioned2024-06-12T10:59:58Z
dc.date.available2024-06-12T10:59:58Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe biologic and microenvironmental factors determining (99m)Tc sestamibi (MIBI) and (99m)Tc tetrofosmin (TF) uptake in breast tumors are incompletely understood, especially in P-glycoprotein (Pgp)-negative tumors. We analyzed the influence of glucose administration on the uptake and retention of MIBI and TF in Pgp-negative tumor-bearing mice in vivo. Twenty (20) mice bearing Ehrlich ascites tumor cell (EATC) xenografts were divided into four groups: (1) MIBI, (2) MIBI+glucose, (3) TF, and (4) TF+glucose. Glucose was administered (5.0 g/kg body weight) intraperitoreally (i.p.) 1 hour before scintigraphy. There were significant differences between the E-UPR MIBI and MIBI+glucose groups (p = 0.009) and minor differences in L-UPR between these groups (p = 0.04). There was a significant inverse correlation between E-UPR of MIBI and glucose levels (r = 0.71, p = 0.02). Comparing the four groups, the highest E-UPR was obtained in the MIBI group (p = 0.006). Other parameters were not different in the MIBI and MIBI+glucose groups and in the TF and TF+glucose groups. Increased blood glucose level affected the MIBI uptake of tumor tissue, particularly for E-UPR. We suggest that these findings were due to basically decreased blood flow and secondarily decreased extracellular pH. However, glucose administration did not affect TF.en_US
dc.identifier.doi10.1089/cbr.2008.0546
dc.identifier.endpage338en_US
dc.identifier.issn1084-9785
dc.identifier.issue3en_US
dc.identifier.pmid19538056en_US
dc.identifier.scopus2-s2.0-67650803447en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage333en_US
dc.identifier.urihttps://doi.org/10.1089/cbr.2008.0546
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20654
dc.identifier.volume24en_US
dc.identifier.wosWOS:000267205100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert Incen_US
dc.relation.ispartofCancer Biotherapy And Radiopharmaceuticalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEATCen_US
dc.subjectGlucoseen_US
dc.subjectMIBIen_US
dc.subjectTetrofosminen_US
dc.subjectBreast-Canceren_US
dc.subjectIn-Vitroen_US
dc.subjectMultidrug-Resistanceen_US
dc.subjectMyocardial-Cellsen_US
dc.subjectBlood-Flowen_US
dc.subjectPhen_US
dc.subjectTc-99m-Mibien_US
dc.subjectTc-99m-Tetrofosminen_US
dc.subjectTechnetium-99m-Tetrofosminen_US
dc.subjectRaten_US
dc.titleGlucose-Induced Alteration of Accumulation of Organotechnetium Complexes Accumulation in Pgp-Negative Tumor-Bearing Miceen_US
dc.typeArticleen_US

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