Glucose-Induced Alteration of Accumulation of Organotechnetium Complexes Accumulation in Pgp-Negative Tumor-Bearing Mice
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mary Ann Liebert Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The biologic and microenvironmental factors determining (99m)Tc sestamibi (MIBI) and (99m)Tc tetrofosmin (TF) uptake in breast tumors are incompletely understood, especially in P-glycoprotein (Pgp)-negative tumors. We analyzed the influence of glucose administration on the uptake and retention of MIBI and TF in Pgp-negative tumor-bearing mice in vivo. Twenty (20) mice bearing Ehrlich ascites tumor cell (EATC) xenografts were divided into four groups: (1) MIBI, (2) MIBI+glucose, (3) TF, and (4) TF+glucose. Glucose was administered (5.0 g/kg body weight) intraperitoreally (i.p.) 1 hour before scintigraphy. There were significant differences between the E-UPR MIBI and MIBI+glucose groups (p = 0.009) and minor differences in L-UPR between these groups (p = 0.04). There was a significant inverse correlation between E-UPR of MIBI and glucose levels (r = 0.71, p = 0.02). Comparing the four groups, the highest E-UPR was obtained in the MIBI group (p = 0.006). Other parameters were not different in the MIBI and MIBI+glucose groups and in the TF and TF+glucose groups. Increased blood glucose level affected the MIBI uptake of tumor tissue, particularly for E-UPR. We suggest that these findings were due to basically decreased blood flow and secondarily decreased extracellular pH. However, glucose administration did not affect TF.
Açıklama
Anahtar Kelimeler
EATC, Glucose, MIBI, Tetrofosmin, Breast-Cancer, In-Vitro, Multidrug-Resistance, Myocardial-Cells, Blood-Flow, Ph, Tc-99m-Mibi, Tc-99m-Tetrofosmin, Technetium-99m-Tetrofosmin, Rat
Kaynak
Cancer Biotherapy And Radiopharmaceuticals
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
24
Sayı
3
