Oxidative stress in the blood of patients with active localized vitiligo

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dc.authoridKurutas, Ergul Belge/0000-0002-6653-4801
dc.authorwosidKurutas, Ergul Belge/CAJ-2682-2022
dc.contributor.authorArican, O.
dc.contributor.authorKurutas, E. B.
dc.date.accessioned2024-06-12T11:17:12Z
dc.date.available2024-06-12T11:17:12Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Vitiligo is an acquired skin disease characterized by white areas on the skin. The pathogenesis of the disease is still unclear. Some findings show that oxidative stress could be an important phenomenon in the pathophysiology of vitiligo. Methods: We evaluated 16 consecutive localized vitiligo patients and 16 healthy controls of a similar age and sex distribution. We measured their indicators of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), glucose 6-phosphate dehydrogenase (G6PD) in erythrocytes, and plasma malondialdehyde (MDA) by spectrophotometry. Results: SOD activities and MDA levels of patients were significantly higher than controls (p < 0.001). CAT and G6PD activities of patients were significantly lower than controls (p < 0.05 and p < 0.001, respectively). Conclusion: Our results confirmed that oxidative stress may play an important role in the pathogenesis of vitiligo. Melanocyte damage in vitiligo might be linked to generalized oxidative stress. This study is the first report on some antioxidant parameters of localized-type vitiligo patients.en_US
dc.identifier.endpage16en_US
dc.identifier.issn1318-4458
dc.identifier.issn1581-2979
dc.identifier.issue1en_US
dc.identifier.pmid18454264en_US
dc.identifier.scopus2-s2.0-42149146165en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage12en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24595
dc.identifier.volume17en_US
dc.identifier.wosWOS:000420824800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDermatovenerological Soc Sloveniaen_US
dc.relation.ispartofActa Dermatovenerologica Alpina Pannonica Et Adriaticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitiligoen_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidant Statusen_US
dc.subjectCatalaseen_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectMalondialdehydeen_US
dc.subjectGlucose 6-Phosphate Dehydrogenaseen_US
dc.titleOxidative stress in the blood of patients with active localized vitiligoen_US
dc.typeArticleen_US

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