Oxidative stress in the blood of patients with active localized vitiligo
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dermatovenerological Soc Slovenia
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: Vitiligo is an acquired skin disease characterized by white areas on the skin. The pathogenesis of the disease is still unclear. Some findings show that oxidative stress could be an important phenomenon in the pathophysiology of vitiligo. Methods: We evaluated 16 consecutive localized vitiligo patients and 16 healthy controls of a similar age and sex distribution. We measured their indicators of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), glucose 6-phosphate dehydrogenase (G6PD) in erythrocytes, and plasma malondialdehyde (MDA) by spectrophotometry. Results: SOD activities and MDA levels of patients were significantly higher than controls (p < 0.001). CAT and G6PD activities of patients were significantly lower than controls (p < 0.05 and p < 0.001, respectively). Conclusion: Our results confirmed that oxidative stress may play an important role in the pathogenesis of vitiligo. Melanocyte damage in vitiligo might be linked to generalized oxidative stress. This study is the first report on some antioxidant parameters of localized-type vitiligo patients.
Açıklama
Anahtar Kelimeler
Vitiligo, Oxidative Stress, Antioxidant Status, Catalase, Superoxide Dismutase, Malondialdehyde, Glucose 6-Phosphate Dehydrogenase
Kaynak
Acta Dermatovenerologica Alpina Pannonica Et Adriatica
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
17
Sayı
1
