Layer-specific strain analysis in patients with suspected stable angina pectoris and apparently normal left ventricular wall motion

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dc.authoridhttp://orcid.org/0000-0001-5328-5749en_US
dc.contributor.authorYilmaztepe, Mustafa Adem
dc.contributor.authorUcar, Fatih Mehmet
dc.date.accessioned2019-12-25T12:05:51Z
dc.date.available2019-12-25T12:05:51Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Anabilim Dalıen_US
dc.description.abstractBackground: Non-invasive imaging tests are widely used in the evaluation of stable angina pectoris (SAP). Despite these tests, non-significant coronary lesions are not a rare finding in patients undergoing elective coronary angiography (CAG). Two-dimensional (2D) speckle tracking global longitudinal strain (GLS) imaging is a more sensitive and accurate technique for measuring LV function than conventional 2D methods. Layer-specific strain analysis is a relatively new method that provides endocardial and epicardial myocardial layer assessment. The aim of the present study was to evaluate longitudinal layer-specific strain (LSS) imaging in patients with suspected SAP. Methods: Patients who underwent CAG for SAP were retrospectively screened. A total of 79 patients with no history of heart disease and wall motion abnormalities were included in the study. Forty-three patients with coronary lesions > 70% constituted the coronary artery disease (CAD) group and 36 patients without significant CAD constituted the control group. Layer-specific GLS transmural, endocardium, and epicardium values (GLS-trans, GLS-endo, and GLS-epi, respectively) were compared between the groups. Results: Patients in the CAD group had significantly lower GLS values in all layers (GLS-trans: -18.2 + 2.4% vs -22.2 + 2.2% p <.001; GLS-endo: -20.8 + 2.8% vs -25.3 + 2.6%, p < .001; GLS-epi: 15.9 + 2.4% vs -19.5 + 1.9%, p < .001). Multivariate adjustment demonstrated GLS-trans as the only independent predictor of CAD (OR:0.472, CI (0.326-0.684), p < .001]. Additionally, the GLS values were all lower in myocardial perfusion scintigraphy (MPS) true-positive patients compared with MPS false-positive patients (GLS-trans: -17.7 +/- 2.4 vs. -21.9 +/- 2.4%, p < .001; GLS-endo: -20.2 +/- 2.9% vs -24.9 +/- 2.9%, P < .001; GLS-epi: 15.4 +/- 2.6% vs. -19.2 +/- 1.8%, P < .001). Conclusion: Resting layer-specific strain as assessed by 2D speckle tracking analysis demonstrated that GLS values were reduced in all layers of myocardium with SAP and with no wall motion abnormalities. LSS analysis can improve the identification of patients with significant CAD but further prospective larger scale studies are needed to put forth the incremental value of LSS analysis over transmural GLS.en_US
dc.identifier.citationYılmaztepe, M. A., & Uçar, F. M. (2018). Layer-specific strain analysis in patients with suspected stable angina pectoris and apparently normal left ventricular wall motion. Cardiovascular ultrasound, 16(1), 25.en_US
dc.identifier.doi10.1186/s12947-018-0144-9en_US
dc.identifier.endpage25en_US
dc.identifier.issn1476-7120
dc.identifier.issue1en_US
dc.identifier.pmid30257673en_US
dc.identifier.scopus2-s2.0-85054068636en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1186/s12947-018-0144-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/4966
dc.identifier.volume16en_US
dc.identifier.wosWOS:000445855600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb fo Sciencesen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.relation.ispartofCardiovascular Ultrasounden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectLeft Ventricle Functionen_US
dc.subjectEchocardiographyen_US
dc.subject2d Speckle Trackingen_US
dc.subjectLayer Specific Strainen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subject2-Dimensional Speckle-Trackingen_US
dc.subjectLongitudinal Strainen_US
dc.subjectMyocardial-Infarctionen_US
dc.subjectDiagnostic Yielden_US
dc.subjectEchocardiographyen_US
dc.subjectDeformationen_US
dc.subjectAngiographyen_US
dc.subjectStenosisen_US
dc.subjectQuantificationen_US
dc.titleLayer-specific strain analysis in patients with suspected stable angina pectoris and apparently normal left ventricular wall motionen_US
dc.typeArticleen_US

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