Preoperative thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer
Küçük Resim Yok
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Int Inst Anticancer Research
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: To identify prognostic factors in stage III and IV endometrial cancer with special attention to pretreatment platelet count. Materials and Methods: 59 patients with FIGO stage III or IV disease operated on between 1983 and 1993 were analyzed. Patients with preoperative thrombocytosis were compared with those without thrombocytosis. Prognostic factors were analyzed with a Cox proportional hazard model. Results: With the exception of age, there were no significant differences between patients with or without thrombocytosis. At multivariate analysis, five-year disease-free survival was influenced significantly by FIGO stage (stage III vs stage IV; p=0.009), thrombocytosis (p=0.02) and cervical involvement (p=0.024). Similarly, overall five-year survival was significantly influenced by stage (p<0.001), cervical involvement (p=0.005) and thrombocytosis (p=0.01). Age, histology, grade, myometrial invasion, lymph-vascular space involvement or spread to adnexae were not significantly associated with survival. Conclusion: Thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer.
Açıklama
Anahtar Kelimeler
Thrombocytosis, Endometrial Cancer, Prognosis, Epithelial Ovarian-Cancer, Cervical-Cancer, Tumor Progression, Platelet Count, Carcinoma, Thrombospondin-1, Survival, Women
Kaynak
Anticancer Research
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
20
Sayı
5C
