The Correlation between New Serological Markers and Disease Phenotype and Activation in Inflammatory Bowel Disease

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dc.authorscopusid14044431400
dc.authorscopusid37360992000
dc.authorscopusid8074922400
dc.authorscopusid12787807200
dc.authorscopusid57893162200
dc.authorscopusid57893655000
dc.authorscopusid35546017100
dc.contributor.authorYorulmaz E.
dc.contributor.authorAdalı G.
dc.contributor.authorYorulmaz H.
dc.contributor.authorTaşan G.
dc.contributor.authorGürses S.
dc.contributor.authorAyaş M.R.
dc.contributor.authorTuncer İ.
dc.date.accessioned2024-06-12T10:26:02Z
dc.date.available2024-06-12T10:26:02Z
dc.date.issued2022
dc.description.abstractBackground: The aim of the study is to assess the correlation between a new antibody panel that is developed against glycans on Crohn’s disease (CD) and ulcerative colitis (UC) differentiative diagnosis and disease properties. Methods: In the study, 137 CD and 122 UC patients and 90 controls were included. Anti-saccharomyces cerevisiae IgG (ASCA), anti-laminaribioside IgG (ALCA), anti-chitobioside IgA (ACCA), and anti-mannobioside IgG (AMCA) were tested in serum. Results: While at least 1 of the other 3 serological markers was positive in 89% of ASCA-positive patients, at least 1 of the other 3 serological markers was positive in 77% of ASCA-negative patients. Positivity ratio for a single anticarbohydrate was ALCA 18 (22%), ACCA 5 (12%), and AMCA 16 (23%). A significant correlation was found between ASCA positivity (P < 0.001) in operated patients and between ASCA, ALCA, and ACCA positivity (P < 0.05) in patients with stricturing and fistulizing CD. According to the ROC analysis, ASCA was found to have the highest area under the curve (0.70-0.82) (correlation coefficient interval 95%). A significant correlation was found between ASCA, ALCA, and ACCA positivity and high serum antibody levels and disease activation (P < 0.05). Conclusion: ASCA, ALCA, and ACCA were found to be correlated with the disease complication and activation in CD. ASCA and ALCA were determined as the best markers in the differentiation between CD and UC. © 2022 The Author(s).en_US
dc.identifier.doi10.34172/mejdd.2022.286
dc.identifier.endpage303en_US
dc.identifier.issn2008-5230
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85138214154en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage294en_US
dc.identifier.urihttps://doi.org/10.34172/mejdd.2022.286
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16649
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherShiraz University of Medical Sciencesen_US
dc.relation.ispartofMiddle East Journal of Digestive Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntiglycan Antibodies; Crohn's Disease; Ulcerative Colitisen_US
dc.subjectAnticarbohydrate; Antichitobioside Immunoglobulin A; Antimannobioside Immunoglobulin G; C Reactive Protein; Corticosteroid; Immunoglobulin G; Immunosuppressive Agent; Laminaribioside Immunoglobin G; Mesalazine; Neutrophil Cytoplasmic Antibody; Tumor Necrosis Factor Inhibitor; Unclassified Drug; Activation Analysis; Adult; Alcohol Consumption; Antibody Detection; Appendectomy; Area Under The Curve; Article; Blood Pressure Monitoring; Body Temperature; Clinical Assessment; Colonoscopy; Comparative Study; Controlled Study; Correlation Analysis; Crohn Disease; Crohn Disease Activity Index; Cross Reaction; Demography; Diagnostic Accuracy; Disease Activity; Disease Localization; Endoscopy; Enzyme Linked Immunosorbent Assay; Erythrocyte Sedimentation Rate; Female; Genotype Phenotype Correlation; Health Check Up; Hemogram; Histopathology; Human; Ileocolonic Involvement; Inflammatory Bowel Disease; Major Clinical Study; Male; Microscopy; Middle Aged; Montreal Classification; Montreal Classification; Optical Density; Pancolitis; Perianal Disease; Predictive Value; Pulse Rate; Radiology; Receiver Operating Characteristic; Rectosigmoid Resection; Saccharomyces Cerevisiae; Sensitivity And Specificity; Serology; Serum; Smoking; Spectrophotometry; Ulcerative Colitisen_US
dc.titleThe Correlation between New Serological Markers and Disease Phenotype and Activation in Inflammatory Bowel Diseaseen_US
dc.typeArticleen_US

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