The Correlation between New Serological Markers and Disease Phenotype and Activation in Inflammatory Bowel Disease
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Shiraz University of Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The aim of the study is to assess the correlation between a new antibody panel that is developed against glycans on Crohn’s disease (CD) and ulcerative colitis (UC) differentiative diagnosis and disease properties. Methods: In the study, 137 CD and 122 UC patients and 90 controls were included. Anti-saccharomyces cerevisiae IgG (ASCA), anti-laminaribioside IgG (ALCA), anti-chitobioside IgA (ACCA), and anti-mannobioside IgG (AMCA) were tested in serum. Results: While at least 1 of the other 3 serological markers was positive in 89% of ASCA-positive patients, at least 1 of the other 3 serological markers was positive in 77% of ASCA-negative patients. Positivity ratio for a single anticarbohydrate was ALCA 18 (22%), ACCA 5 (12%), and AMCA 16 (23%). A significant correlation was found between ASCA positivity (P < 0.001) in operated patients and between ASCA, ALCA, and ACCA positivity (P < 0.05) in patients with stricturing and fistulizing CD. According to the ROC analysis, ASCA was found to have the highest area under the curve (0.70-0.82) (correlation coefficient interval 95%). A significant correlation was found between ASCA, ALCA, and ACCA positivity and high serum antibody levels and disease activation (P < 0.05). Conclusion: ASCA, ALCA, and ACCA were found to be correlated with the disease complication and activation in CD. ASCA and ALCA were determined as the best markers in the differentiation between CD and UC. © 2022 The Author(s).
Açıklama
Anahtar Kelimeler
Antiglycan Antibodies; Crohn's Disease; Ulcerative Colitis, Anticarbohydrate; Antichitobioside Immunoglobulin A; Antimannobioside Immunoglobulin G; C Reactive Protein; Corticosteroid; Immunoglobulin G; Immunosuppressive Agent; Laminaribioside Immunoglobin G; Mesalazine; Neutrophil Cytoplasmic Antibody; Tumor Necrosis Factor Inhibitor; Unclassified Drug; Activation Analysis; Adult; Alcohol Consumption; Antibody Detection; Appendectomy; Area Under The Curve; Article; Blood Pressure Monitoring; Body Temperature; Clinical Assessment; Colonoscopy; Comparative Study; Controlled Study; Correlation Analysis; Crohn Disease; Crohn Disease Activity Index; Cross Reaction; Demography; Diagnostic Accuracy; Disease Activity; Disease Localization; Endoscopy; Enzyme Linked Immunosorbent Assay; Erythrocyte Sedimentation Rate; Female; Genotype Phenotype Correlation; Health Check Up; Hemogram; Histopathology; Human; Ileocolonic Involvement; Inflammatory Bowel Disease; Major Clinical Study; Male; Microscopy; Middle Aged; Montreal Classification; Montreal Classification; Optical Density; Pancolitis; Perianal Disease; Predictive Value; Pulse Rate; Radiology; Receiver Operating Characteristic; Rectosigmoid Resection; Saccharomyces Cerevisiae; Sensitivity And Specificity; Serology; Serum; Smoking; Spectrophotometry; Ulcerative Colitis
Kaynak
Middle East Journal of Digestive Diseases
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
14
Sayı
3
