Contrast-induced nephropathy: preventive and protective effects of melatonin

Basit Öğe Kaydı
dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorGazi, Sabri
dc.contributor.authorAltun, Armagan
dc.contributor.authorErdogan, Okan
dc.date.accessioned2024-06-12T10:51:42Z
dc.date.available2024-06-12T10:51:42Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractInfusion of contrast agents increases osmotic load, viscosity, hypoxemia of the renal medulla and renal free radical production through post-ischemic oxidative stress. The present experimental study sought to determine whether melatonin, because of its anti-oxidant properties might have a preventive and protective role against the development of contrast-induced nephropathy (CIN). Twenty-four adult male rats were divided into four experimental groups: healthy control rats (CR), rats with CIN (CINR), rats with CIN pretreated with melatonin (CINR1M), and rats with CIN pre- and post-treated with melatonin (CINR2M). In CINR, both serum creatinine (Cr) level and fractional excretion of sodium (FE-Na) significantly increased, whereas Cr clearance decreased at post-CIN compared with pre-CIN period. Rats in CINR1M did not show any improvement in renal function. Cr clearance decreased, whereas both serum Cr level and FE-Na increased in rats pretreated with melatonin. In contrast, significant improvements were observed in CINR2M. Serum Cr and Cr clearance did not change, whereas FE-Na significantly reduced in rats pre- and post-treated with melatonin. In conclusion, the present experimental study clearly demonstrated the preventive and protective role of melatonin against the development of CIN.en_US
dc.identifier.doi10.1111/j.1600-079X.2006.00336.x
dc.identifier.endpage57en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue1en_US
dc.identifier.pmid16842541en_US
dc.identifier.scopus2-s2.0-33745581646en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2006.00336.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18461
dc.identifier.volume41en_US
dc.identifier.wosWOS:000238655500008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiographyen_US
dc.subjectAntioxidanten_US
dc.subjectContrast Agenten_US
dc.subjectMelatoninen_US
dc.subjectNephropathyen_US
dc.subjectRadiocontrast-Induced Nephropathyen_US
dc.subjectInduced Lipid-Peroxidationen_US
dc.subjectAcute-Renal-Failureen_US
dc.subjectOxidative Stressen_US
dc.subjectN-1-Acetyl-N (2)-Formyl-5-Methoxykynuramineen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectEpithelial-Cellsen_US
dc.subjectFree-Radicalsen_US
dc.subjectNitric-Oxideen_US
dc.subjectRat-Kidneyen_US
dc.titleContrast-induced nephropathy: preventive and protective effects of melatoninen_US
dc.typeArticleen_US

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