Contrast-induced nephropathy: preventive and protective effects of melatonin
Küçük Resim Yok
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Infusion of contrast agents increases osmotic load, viscosity, hypoxemia of the renal medulla and renal free radical production through post-ischemic oxidative stress. The present experimental study sought to determine whether melatonin, because of its anti-oxidant properties might have a preventive and protective role against the development of contrast-induced nephropathy (CIN). Twenty-four adult male rats were divided into four experimental groups: healthy control rats (CR), rats with CIN (CINR), rats with CIN pretreated with melatonin (CINR1M), and rats with CIN pre- and post-treated with melatonin (CINR2M). In CINR, both serum creatinine (Cr) level and fractional excretion of sodium (FE-Na) significantly increased, whereas Cr clearance decreased at post-CIN compared with pre-CIN period. Rats in CINR1M did not show any improvement in renal function. Cr clearance decreased, whereas both serum Cr level and FE-Na increased in rats pretreated with melatonin. In contrast, significant improvements were observed in CINR2M. Serum Cr and Cr clearance did not change, whereas FE-Na significantly reduced in rats pre- and post-treated with melatonin. In conclusion, the present experimental study clearly demonstrated the preventive and protective role of melatonin against the development of CIN.
Açıklama
Anahtar Kelimeler
Angiography, Antioxidant, Contrast Agent, Melatonin, Nephropathy, Radiocontrast-Induced Nephropathy, Induced Lipid-Peroxidation, Acute-Renal-Failure, Oxidative Stress, N-1-Acetyl-N (2)-Formyl-5-Methoxykynuramine, Antioxidant Enzymes, Epithelial-Cells, Free-Radicals, Nitric-Oxide, Rat-Kidney
Kaynak
Journal Of Pineal Research
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
41
Sayı
1
