Arginine mediated photodynamic therapy with silicon(IV) phthalocyanine photosensitizers

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dc.authoridBalcik Ercin, Pelin/0000-0002-3470-0393
dc.authorwosidGöksel, Meltem/C-1548-2018
dc.authorwosidBalcik Ercin, Pelin/AAB-8512-2022
dc.contributor.authorBalcik-Ercin, Pelin
dc.contributor.authorEkineker, Gulcin
dc.contributor.authorSalik, Nazli
dc.contributor.authorAydogdu, Bahar
dc.contributor.authorYagci, Tamer
dc.contributor.authorGoksel, Meltem
dc.date.accessioned2024-06-12T11:16:01Z
dc.date.available2024-06-12T11:16:01Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn the current study, we synthesized a new SiPc derivative conjugated with arginine at the axial positions, for a novel phthalocyanine-based photosensitizer for photodynamic therapy (PDT) applications in cancer cells. Axially-di-arginine substituted new silicon(IV) phthalocyanine photosensitizer (PS-5a) has been thoroughly researched for its anti-cancer properties. Various spectroscopic techniques were used to characterize this conjugate, including 1H NMR, 13C NMR, FT-IR, UV-vis, and MS spectral data. The in vitro PDT activities of the conjugate on cancer cells were tested through its cytotoxic, clonogenic, apoptotic effects on, and its capacity to induce DNA damage, and the disruption of mitochondrial membrane potential in cancer cell lines (liver; HuH-7, cervix; HeLa and breast; MCF7). Cancer cells exposed to the light illumination following uptake of the PS-5a as a photosensitizer revealed DNA breakage and collapsed mitochondrial membrane potential. The results of the present investigation demonstrate that PS-5a has a significant photo-cytotoxic effect on cancer cells. So, axiallydi-arginine substituted silicon(IV) phthalocyanine could be an effective PDT agent for PDT treatment.en_US
dc.description.sponsorshipScientific amp; Technological Research Council of Turkey (TUBITAK) [117Z395]en_US
dc.description.sponsorshipThis study was supported by The Scientific & Technological Research Council of Turkey (TUBITAK, project no: 117Z395).en_US
dc.identifier.doi10.1016/j.pdpdt.2023.103667
dc.identifier.issn1572-1000
dc.identifier.issn1873-1597
dc.identifier.pmid37355078en_US
dc.identifier.scopus2-s2.0-85166676941en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2023.103667
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24164
dc.identifier.volume43en_US
dc.identifier.wosWOS:001040047300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPhotodiagnosis And Photodynamic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTargeted Agenten_US
dc.subjectPhotodynamic Therapyen_US
dc.subjectSilicon(IV) Phthalocyanineen_US
dc.subjectArginineen_US
dc.subjectDNA Damageen_US
dc.subjectThe Cytotoxic Effecten_US
dc.subjectZinc(Ii) Phthalocyanineen_US
dc.subjectCanceren_US
dc.titleArginine mediated photodynamic therapy with silicon(IV) phthalocyanine photosensitizersen_US
dc.typeArticleen_US

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