Arginine mediated photodynamic therapy with silicon(IV) phthalocyanine photosensitizers
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the current study, we synthesized a new SiPc derivative conjugated with arginine at the axial positions, for a novel phthalocyanine-based photosensitizer for photodynamic therapy (PDT) applications in cancer cells. Axially-di-arginine substituted new silicon(IV) phthalocyanine photosensitizer (PS-5a) has been thoroughly researched for its anti-cancer properties. Various spectroscopic techniques were used to characterize this conjugate, including 1H NMR, 13C NMR, FT-IR, UV-vis, and MS spectral data. The in vitro PDT activities of the conjugate on cancer cells were tested through its cytotoxic, clonogenic, apoptotic effects on, and its capacity to induce DNA damage, and the disruption of mitochondrial membrane potential in cancer cell lines (liver; HuH-7, cervix; HeLa and breast; MCF7). Cancer cells exposed to the light illumination following uptake of the PS-5a as a photosensitizer revealed DNA breakage and collapsed mitochondrial membrane potential. The results of the present investigation demonstrate that PS-5a has a significant photo-cytotoxic effect on cancer cells. So, axiallydi-arginine substituted silicon(IV) phthalocyanine could be an effective PDT agent for PDT treatment.
Açıklama
Anahtar Kelimeler
Targeted Agent, Photodynamic Therapy, Silicon(IV) Phthalocyanine, Arginine, DNA Damage, The Cytotoxic Effect, Zinc(Ii) Phthalocyanine, Cancer
Kaynak
Photodiagnosis And Photodynamic Therapy
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
43
