HISTOLOGICAL PERSPECTIVE ON THE EFFECTS OF TUMOR-ASSOCIATED MACROPHAGES IN THE TUMOR MICROENVIRONMENT SURROUNDING PAPILLARY THYROID CARCINOMA

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dc.authoridCelik, Mehmet/0000-0001-7364-370X
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridAytürk Salt, Semra/0000-0002-1560-3459;
dc.authorwosidCelik, Mehmet/AAA-8773-2021
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidAytürk Salt, Semra/U-4265-2017
dc.authorwosidCan, Nuray/D-3452-2016
dc.authorwosidOzyilmaz, Filiz/A-4865-2016
dc.contributor.authorCan, Nuray Y.
dc.contributor.authorAyturk, Semra
dc.contributor.authorCelik, Mehmet
dc.contributor.authorSezer, Yavuz A.
dc.contributor.authorOzyilmaz, Eiliz
dc.contributor.authorTastekin, Ebru
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:16:44Z
dc.date.available2024-06-12T11:16:44Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTumor-associated macrophages (TAMs) are one of the most noticeable elements of the tumor microenvironment. The present study investigated the relationships between the density of CD163 immunolabeled M2-like TAMs with other histological properties of the tumor microenvironment and clinipathological features in 90 patients with papillary thyroid carcinomas (PTC). The percentage of TAMs was higher in tumors with significant lymphocytic tumor response (p = 0.020), in tumors with a significant degree of stromal tumor response (p = 0.014), those with infiltrative tumor borders (p = 0.029), in conventional variant papillary carcinoma (p = 0.032), and in patients with autoantibodies for thyroid peroxidase (p = 0.014). The tumors associated with lymphocytic thyroiditis had lower numbers of TAMs (p = 0.027). In conclusion, for the first time, the present study attempts to establish a full assessment of interactions of CD163 expressing M2-like TAMs with the triad of primary tumor-tumor microenvironment-tumor behavior and above all, with markers of autoimmunity. Thus, these alternatively polarized macrophages may act in tumor progression and dissemination according to their various products, which may be ordered by tumor cells or neighboring immune cells. The molecular studies may reveal their roles in various tumors and may improve the therapy strategies targeting TAMs in various malignant tumors, including PTCs.en_US
dc.identifier.doi10.5114/PJP.2016.65865
dc.identifier.endpage344en_US
dc.identifier.issn1233-9687
dc.identifier.issue4en_US
dc.identifier.pmid28547960en_US
dc.identifier.scopus2-s2.0-85012186690en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage332en_US
dc.identifier.urihttps://doi.org/10.5114/PJP.2016.65865
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24429
dc.identifier.volume67en_US
dc.identifier.wosWOS:000394202200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVesalius Univ Medical Publen_US
dc.relation.ispartofPolish Journal Of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTumor Associated Macrophagesen_US
dc.subjectPapillary Thyroid Carcinomaen_US
dc.subjectTumor Microenvironmenten_US
dc.subjectLymph-Node Metastasisen_US
dc.subjectFollicular Varianten_US
dc.subjectCellsen_US
dc.subjectCanceren_US
dc.subjectExpressionen_US
dc.subjectPolarizationen_US
dc.subjectProgressionen_US
dc.subjectPrognosisen_US
dc.subjectParadigmen_US
dc.subjectDensityen_US
dc.titleHISTOLOGICAL PERSPECTIVE ON THE EFFECTS OF TUMOR-ASSOCIATED MACROPHAGES IN THE TUMOR MICROENVIRONMENT SURROUNDING PAPILLARY THYROID CARCINOMAen_US
dc.typeArticleen_US

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