HISTOLOGICAL PERSPECTIVE ON THE EFFECTS OF TUMOR-ASSOCIATED MACROPHAGES IN THE TUMOR MICROENVIRONMENT SURROUNDING PAPILLARY THYROID CARCINOMA
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Vesalius Univ Medical Publ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Tumor-associated macrophages (TAMs) are one of the most noticeable elements of the tumor microenvironment. The present study investigated the relationships between the density of CD163 immunolabeled M2-like TAMs with other histological properties of the tumor microenvironment and clinipathological features in 90 patients with papillary thyroid carcinomas (PTC). The percentage of TAMs was higher in tumors with significant lymphocytic tumor response (p = 0.020), in tumors with a significant degree of stromal tumor response (p = 0.014), those with infiltrative tumor borders (p = 0.029), in conventional variant papillary carcinoma (p = 0.032), and in patients with autoantibodies for thyroid peroxidase (p = 0.014). The tumors associated with lymphocytic thyroiditis had lower numbers of TAMs (p = 0.027). In conclusion, for the first time, the present study attempts to establish a full assessment of interactions of CD163 expressing M2-like TAMs with the triad of primary tumor-tumor microenvironment-tumor behavior and above all, with markers of autoimmunity. Thus, these alternatively polarized macrophages may act in tumor progression and dissemination according to their various products, which may be ordered by tumor cells or neighboring immune cells. The molecular studies may reveal their roles in various tumors and may improve the therapy strategies targeting TAMs in various malignant tumors, including PTCs.
Açıklama
Anahtar Kelimeler
Tumor Associated Macrophages, Papillary Thyroid Carcinoma, Tumor Microenvironment, Lymph-Node Metastasis, Follicular Variant, Cells, Cancer, Expression, Polarization, Progression, Prognosis, Paradigm, Density
Kaynak
Polish Journal Of Pathology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
67
Sayı
4
