Anti-ischaemic and anti-anginal effects of nisoldipine and ramipril in patients with cardiological syndrome X

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dc.authorscopusid56452820900
dc.authorscopusid7005722551
dc.authorscopusid7004571678
dc.contributor.authorOzcelik F.
dc.contributor.authorAltun A.
dc.contributor.authorOzbay G.
dc.date.accessioned2024-06-12T10:28:21Z
dc.date.available2024-06-12T10:28:21Z
dc.date.issued1998
dc.description.abstractWe investigated anti-ischaemic and anti-anginal effects of nisoldipine and ramipril in patients with the cardiological syndrome X. After a two-week wash-out period, 18 patients (7 men, 11 women; mean age: 46±10 years) with cardiological syndrome X (stable angina pectoris, positive exercise test, negative ergonovine test, and normal coronary angiography) were given nisoldipine 5 mg twice daily for four weeks. And after a second two-week wash-out period, the same patients were given ramipril 2.5 mg daily for four weeks. Treadmill exercise test with modified Bruce protocol was performed at the end of each period. The time until anginal attack occurred (p=0.006 vs p=0.02), total exercise time (p=0.0008 vs p=0.02), and mean metabolic equivalent (p=0.0016 vs p=0.01) were increased significantly after nisoldipine and ramipril therapy periods. The time until ST segment depression by 1mm occurred (p=0.002) was increased significantly after nisoldipine therapy. The time until ST segment depression recovery (p=0.016 vs p=0.012), the weekly number of angina pectoris (p=0.00 vs p=0.028), and the weekly number of sublingual nitroglycerin consumption (p=0.00 vs p=0.012) were decreased significantly after nisoldipine and ramipril therapy periods. We conclude that 10 mg/daily nisoldipine or 2.5 mg/daily has anti-ischaemic and anti-anginal effects in patients with cardiological syndrome X.en_US
dc.identifier.endpage217+197en_US
dc.identifier.issn1016-5169
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-0031744582en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17198
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiotensin Converting Enzyme Inhibitor; Calcium Channel Blocker; Cardiological Syndrome Xen_US
dc.subjectNisoldipine; Ramipril; Adult; Article; Clinical Article; Female; Human; Male; St Segment Depression; Syndrome X; Treadmill Exercise; Treatment Outcomeen_US
dc.titleAnti-ischaemic and anti-anginal effects of nisoldipine and ramipril in patients with cardiological syndrome Xen_US
dc.title.alternativeKardiyolojik sendrom X'li hastalarda nisoldipin ve ramipril'in anti- iskemik ve anti-anginal etkilerien_US
dc.typeArticleen_US

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