Anti-ischaemic and anti-anginal effects of nisoldipine and ramipril in patients with cardiological syndrome X
Küçük Resim Yok
Tarih
1998
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We investigated anti-ischaemic and anti-anginal effects of nisoldipine and ramipril in patients with the cardiological syndrome X. After a two-week wash-out period, 18 patients (7 men, 11 women; mean age: 46±10 years) with cardiological syndrome X (stable angina pectoris, positive exercise test, negative ergonovine test, and normal coronary angiography) were given nisoldipine 5 mg twice daily for four weeks. And after a second two-week wash-out period, the same patients were given ramipril 2.5 mg daily for four weeks. Treadmill exercise test with modified Bruce protocol was performed at the end of each period. The time until anginal attack occurred (p=0.006 vs p=0.02), total exercise time (p=0.0008 vs p=0.02), and mean metabolic equivalent (p=0.0016 vs p=0.01) were increased significantly after nisoldipine and ramipril therapy periods. The time until ST segment depression by 1mm occurred (p=0.002) was increased significantly after nisoldipine therapy. The time until ST segment depression recovery (p=0.016 vs p=0.012), the weekly number of angina pectoris (p=0.00 vs p=0.028), and the weekly number of sublingual nitroglycerin consumption (p=0.00 vs p=0.012) were decreased significantly after nisoldipine and ramipril therapy periods. We conclude that 10 mg/daily nisoldipine or 2.5 mg/daily has anti-ischaemic and anti-anginal effects in patients with cardiological syndrome X.
Açıklama
Anahtar Kelimeler
Angiotensin Converting Enzyme Inhibitor; Calcium Channel Blocker; Cardiological Syndrome X, Nisoldipine; Ramipril; Adult; Article; Clinical Article; Female; Human; Male; St Segment Depression; Syndrome X; Treadmill Exercise; Treatment Outcome
Kaynak
Turk Kardiyoloji Dernegi Arsivi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
26
Sayı
4
