The effects of ketotifen as a mast cell stabilizer on the development of adjuvant-induced arthritis in rats

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dc.authorscopusid6507213105
dc.authorscopusid6507895109
dc.authorscopusid6603935299
dc.authorscopusid55908979100
dc.authorscopusid6603653874
dc.authorscopusid6603559061
dc.contributor.authorKadaifci R.
dc.contributor.authorKadaifci O.
dc.contributor.authorUlugol A.
dc.contributor.authorUnalan H.
dc.contributor.authorKaradag H.
dc.contributor.authorDokmeci I.
dc.date.accessioned2024-06-12T10:29:30Z
dc.date.available2024-06-12T10:29:30Z
dc.date.issued1995
dc.description.abstractThe effects of ketotifen as a mast cell stabilizer on adjuvant-induced arthritis in rats were investigated. Adjuvant arthritis (AA) is widely used to evaluate the antiarthritic drugs since this disease have many similarities to rheumatoid arthritis in humans. The mast cells increase in the histopathological picture of joints in both these diseases. We comparatively examined the effects of ketotifen that stabilizes mast cells and astemizol that is an antagonist of histamine H1 receptors to investigate the role of the mast cells on development of these diseases. The therapy with ketotifen (0.05 mg/kg/day) is continued for two weeks and it suppressed the developing of the secondary lesions of the disease, however, the effects of ketotifen depend on much more stabilization of mast cells than its H1-antihistaminic effects and that the mast cells stabilizators may have benefit on the therapy of rheumatic patients.en_US
dc.identifier.endpage295en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-0029068958en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage291en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17766
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofFizik Tedavi Rehabilitasyon Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdjuvant-Induced Arthritis; Ketotifenen_US
dc.subjectAstemizole; Histamine H1 Receptor Antagonist; Ketotifen; Mast Cell Stabilizer; Unclassified Drug; Animal Experiment; Animal Model; Arthritis; Article; Nonhuman; Raten_US
dc.titleThe effects of ketotifen as a mast cell stabilizer on the development of adjuvant-induced arthritis in ratsen_US
dc.title.alternativeMAST HUCRE STABILIZATORU KETOTIFENIN SICANLARDAKI ADJUVANT ARTRITI UZERINE ETKILERIen_US
dc.typeArticleen_US

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