Systemic Cannabidiol Does Not Reduce Compound 48/80-Induced Itching Behavior in Mice

Basit Öğe Kaydı
dc.contributor.authorDemirel, Hatice
dc.contributor.authorBaksın, Elif
dc.contributor.authorÖzgür, Ece Önay
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorUlugöl, Ahmet
dc.date.accessioned2021-11-20T10:26:28Z
dc.date.available2021-11-20T10:26:28Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalıen_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Anabilim Dalıen_US
dc.description.abstractAims: Cannabinoids are chemical compounds including natural cannabinoids found in the Cannabis plant, their synthetic counterparts, and endocannabinoids. Cannabidiol, a phytocannabinoid derived from the Cannabis plant, exerts anticonvulsant, anxiolytic, anti-inflammatory, neuroprotective, analgesic effects. Although there are many similarities between the pathophysiological mechanisms of pain and itch, researches that investigate the effect of cannabinoids on itching are insufficient. Here, we aimed to examine the antipruritic effect of cannabidiol and the contribution of spinal cannabinoid receptors. Methods: Male Balb/c mice, weighing 20-30 g, were used. Itching behavior was produced by intradermal injection of compound 48/80 (100 ?g/50 ?l); cannabidiol (1, 3, 10 mg/kg, ip) was administered 30 minutes before compound 48/80 injections. Then, scratching of the injected site by the hind paws was videotaped for 30 minutes. Locomotor performances were assessed using a rotarod apparatus. Results: Cannabidiol had no effect on compound 48/80-induced itching behavior at any dose given; moreover, cannabidiol did not produce any impairment on motor function. AM-251, a cannabinoid receptor type 1 antagonist, and AM-630, a cannabinoid receptor type 2 antagonist were administered intrathecally to observe the contribution of spinal cannabinoid receptors to the antipruritic action of cannabidiol. We observed that cannabidol did not possess any effect on itching behaviour. Conclusion: Our results indicate that systemic administration of cannabidiol does not attenuate compound 48/80 induced itching behavior in miceen_US
dc.identifier.dergipark541683en_US
dc.identifier.issn2148-4724
dc.identifier.issn2548-0030
dc.identifier.issue1en_US
dc.identifier.urihttps://dergipark.org.tr/tr/pub/tmsj/issue/43969/541683
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/674000
dc.identifier.urihttps://hdl.handle.net/20.500.14551/6062
dc.identifier.volume6en_US
dc.language.isoenen_US
dc.publisherTrakya Üniversitesien_US
dc.relation.ispartofTurkish Medical Student Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCannabidiolen_US
dc.subjectcompound 48-80en_US
dc.subjectpruritusen_US
dc.titleSystemic Cannabidiol Does Not Reduce Compound 48/80-Induced Itching Behavior in Miceen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
6062.pdf
Boyut:
281.3 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Turkish Medical Student Journal
Makale Koleksiyonu
Makale Koleksiyonu