Effect of coronary sinus diastolic balloon pulsation on ischemic myocardium

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dc.authorscopusid7003875728
dc.authorscopusid6603338566
dc.authorscopusid6603065880
dc.authorscopusid56989207000
dc.authorscopusid57188694249
dc.contributor.authorCanbaz S.
dc.contributor.authorKolbakir F.
dc.contributor.authorKeçeligil H.T.
dc.contributor.authorDemir Z.
dc.contributor.authorErk M.K.
dc.date.accessioned2024-06-12T10:28:32Z
dc.date.available2024-06-12T10:28:32Z
dc.date.issued2001
dc.description.abstractObjectives: To evaluate the effect of coronary sinus diastolic balloon pulsation (CSDBP) on acute myocardial ischemia and infarction. It was hypothesized that this procedure would improve retrograde flow to ischemic areas and allow for more complete oxygen exchange and venous washout of metabolites, with elevated coronary sinus pressure and retrograde pulsation. Animals and methods: This two-part study was done on 10 dogs. First, CSDBP was applied to normal myocardium by a balloon catheter and a pump system at beat to beat cardiac cycles of 1:1, 2:1 and 3:1. Then coronary ischemia was obtained by coronary artery ligation and the procedure was repeated. Electrocardiographic (ECG), arterial and coronary sinus pressure alterations were monitored continuously, and arterial, mixed venous and coronary sinus blood lactate concentrations were measured at each stage of the study. Results: In the first stage no hemodynamic deterioration was observed. In the second stage, mean ECG-ST segment elevation was 6.30±0.95 mm (P<0.01) and coronary sinus blood lactate concentration increased to 5.37±0.37 mmol/L from 1.95±0.31 mmol/L (P<0.01). ECG-ST segment elevation decreased to 3.73±0.64 mm and coronary sinus blood lactate concentration decreased to 4.79±0.28 mmol/L (P<0.05) with 1:1 beat to beat CSDBP. ECG-ST segment elevation decreased to 2.95±0.73 mm and coronary sinus blood lactate concentration decreased to 4.4±0.22 mmol/L with 2:1 CSDBP. ECG-ST segment elevation decreased to 3.6±0.42 mm and coronary sinus blood lactate concentration decreased to 4.17±0.22 mmol/L with 3:1 CSDBP as well. Discussion: Results showed that CSDBP technique lowered the increased ECG-ST segment elevation and myocardial lactate production.en_US
dc.identifier.endpage104en_US
dc.identifier.issn1205-6626
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0034928594en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17273
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofExperimental and Clinical Cardiologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Sinus; Diastolic Balloon Pulsationen_US
dc.subjectLactic Acid; Oxygen; Clinical Trial; Concentration Response; Conference Paper; Coronary Sinus Blood Flow; Coronary Sinus Diastolic Balloon Pulsation; Counterpulsation; Diastolic Blood Pressure; Dog; Electroencephalogram; Heart Infarction; Heart Muscle Ischemia; Hemodynamic Monitoring; Human; Lactate Blood Level; Metabolite; Oxygen Transport; St Segment Elevation; Technique; Treatment Outcomeen_US
dc.titleEffect of coronary sinus diastolic balloon pulsation on ischemic myocardiumen_US
dc.typeConference Objecten_US

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