Effect of coronary sinus diastolic balloon pulsation on ischemic myocardium
Küçük Resim Yok
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: To evaluate the effect of coronary sinus diastolic balloon pulsation (CSDBP) on acute myocardial ischemia and infarction. It was hypothesized that this procedure would improve retrograde flow to ischemic areas and allow for more complete oxygen exchange and venous washout of metabolites, with elevated coronary sinus pressure and retrograde pulsation. Animals and methods: This two-part study was done on 10 dogs. First, CSDBP was applied to normal myocardium by a balloon catheter and a pump system at beat to beat cardiac cycles of 1:1, 2:1 and 3:1. Then coronary ischemia was obtained by coronary artery ligation and the procedure was repeated. Electrocardiographic (ECG), arterial and coronary sinus pressure alterations were monitored continuously, and arterial, mixed venous and coronary sinus blood lactate concentrations were measured at each stage of the study. Results: In the first stage no hemodynamic deterioration was observed. In the second stage, mean ECG-ST segment elevation was 6.30±0.95 mm (P<0.01) and coronary sinus blood lactate concentration increased to 5.37±0.37 mmol/L from 1.95±0.31 mmol/L (P<0.01). ECG-ST segment elevation decreased to 3.73±0.64 mm and coronary sinus blood lactate concentration decreased to 4.79±0.28 mmol/L (P<0.05) with 1:1 beat to beat CSDBP. ECG-ST segment elevation decreased to 2.95±0.73 mm and coronary sinus blood lactate concentration decreased to 4.4±0.22 mmol/L with 2:1 CSDBP. ECG-ST segment elevation decreased to 3.6±0.42 mm and coronary sinus blood lactate concentration decreased to 4.17±0.22 mmol/L with 3:1 CSDBP as well. Discussion: Results showed that CSDBP technique lowered the increased ECG-ST segment elevation and myocardial lactate production.
Açıklama
Anahtar Kelimeler
Coronary Sinus; Diastolic Balloon Pulsation, Lactic Acid; Oxygen; Clinical Trial; Concentration Response; Conference Paper; Coronary Sinus Blood Flow; Coronary Sinus Diastolic Balloon Pulsation; Counterpulsation; Diastolic Blood Pressure; Dog; Electroencephalogram; Heart Infarction; Heart Muscle Ischemia; Hemodynamic Monitoring; Human; Lactate Blood Level; Metabolite; Oxygen Transport; St Segment Elevation; Technique; Treatment Outcome
Kaynak
Experimental and Clinical Cardiology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
6
Sayı
2
