68Ga-PSMA-I&T-PET/CT interobserver and intraobserver agreement for prostate cancer: a lesion based and subregional comparison study among observers with different levels of experience

Basit Öğe Kaydı
dc.authoridKorkmaz, Ulku/0000-0002-7155-7610
dc.authorwosidozdemir gunay, busra/GZG-8863-2022
dc.authorwosidKorkmaz, Ulku/AAJ-4430-2020
dc.contributor.authorSoyluoglu, Selin
dc.contributor.authorKorkmaz, Ulku
dc.contributor.authorOzdemir, Busra
dc.contributor.authorUstun, Funda
dc.contributor.authorDurmus-Altun, Gulay
dc.date.accessioned2024-06-12T10:51:02Z
dc.date.available2024-06-12T10:51:02Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective Ga-68-PSMA-PET/CT is a relatively new technique, that is rapidly becoming widespread. We aimed to contribute interobserver-intraobserver agreement of Ga-68-PSMA-PET/CT, among low/high-experienced interpreters. Methods Ga-68-PSMA-PET/CT of 56 patients with prostate cancer were evaluated blindly by four observers. Visual interpretation of malignant disease and SUVmax for lymph node (LN) regions, local tumor, bones and visceral organs were recorded. Cohen's Kappa and Fleiss' Kappa analyses were used to measure agreement between low/high/all-experienced observers. Variations were compared for regions, and the effect of prostate-specific antigen or Gleason score on the results was investigated. Results Interobserver agreement was almost perfect for all LN regions (LN1 low-experienced kappa: 0.84/0.84, high-experienced 0.89/0.96; LN2 low-experienced kappa: 0.88/0.79, high-experienced 0.95/0.95; LN3 low-experienced kappa: 0.84/0.89, high-experienced 0.87/0.94, first/second readings, respectively) and bone lesions (low-experienced kappa: 0.88/0.88, high-experienced 0.92/0.92, first/second readings, respectively). For local tumor, interobserver agreement was substantially-almost perfect among a high-experienced group (kappa: 0.74/0.89, first/second readings, respectively), and was moderate-substantial among a low-experienced group (kappa: 0.62/0.56, first/second readings, respectively). Intraobserver agreement was almost perfect for three observers for all regions and substantial for the observer with the lowest experience in LN3, local and visceral lesions (kappa: 0.74/0.79/0.62, respectively). Conclusion Interpretation of prostate-specific membrane antigen (PSMA) for prostate cancer is acceptably consistent among observers, but some details are noteworthy. The evaluation should be done more algorithmically for local tumors, since all observers showed relatively lower agreement. The agreement increased as prostate-specific antigen and Gleason score increased. The observer with PSMA experience <30 readings showed lower reliability, distinct from the others. This indicates that although a reader may be familiar with other PET agents, a more consistent interpretation of Ga-68-PSMA-PET/CT requires training with a small number of identified cases.en_US
dc.identifier.doi10.1097/MNM.0000000000001438
dc.identifier.endpage1129en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue10en_US
dc.identifier.pmid34001829en_US
dc.identifier.scopus2-s2.0-85115966484en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1122en_US
dc.identifier.urihttps://doi.org/10.1097/MNM.0000000000001438
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18209
dc.identifier.volume42en_US
dc.identifier.wosWOS:000697268300008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgreementen_US
dc.subjectInterobserveren_US
dc.subjectIntraobserveren_US
dc.subjectProstate Canceren_US
dc.subjectPETen_US
dc.subjectCTen_US
dc.subjectGa-68-Labeled Psma Liganden_US
dc.subjectBone-Scintigraphyen_US
dc.subjectGa-68-Psma Pet/Cten_US
dc.subjectMetastasesen_US
dc.subjectDiagnosisen_US
dc.subjectPet/Mrien_US
dc.title68Ga-PSMA-I&T-PET/CT interobserver and intraobserver agreement for prostate cancer: a lesion based and subregional comparison study among observers with different levels of experienceen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu