68Ga-PSMA-I&T-PET/CT interobserver and intraobserver agreement for prostate cancer: a lesion based and subregional comparison study among observers with different levels of experience
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective Ga-68-PSMA-PET/CT is a relatively new technique, that is rapidly becoming widespread. We aimed to contribute interobserver-intraobserver agreement of Ga-68-PSMA-PET/CT, among low/high-experienced interpreters. Methods Ga-68-PSMA-PET/CT of 56 patients with prostate cancer were evaluated blindly by four observers. Visual interpretation of malignant disease and SUVmax for lymph node (LN) regions, local tumor, bones and visceral organs were recorded. Cohen's Kappa and Fleiss' Kappa analyses were used to measure agreement between low/high/all-experienced observers. Variations were compared for regions, and the effect of prostate-specific antigen or Gleason score on the results was investigated. Results Interobserver agreement was almost perfect for all LN regions (LN1 low-experienced kappa: 0.84/0.84, high-experienced 0.89/0.96; LN2 low-experienced kappa: 0.88/0.79, high-experienced 0.95/0.95; LN3 low-experienced kappa: 0.84/0.89, high-experienced 0.87/0.94, first/second readings, respectively) and bone lesions (low-experienced kappa: 0.88/0.88, high-experienced 0.92/0.92, first/second readings, respectively). For local tumor, interobserver agreement was substantially-almost perfect among a high-experienced group (kappa: 0.74/0.89, first/second readings, respectively), and was moderate-substantial among a low-experienced group (kappa: 0.62/0.56, first/second readings, respectively). Intraobserver agreement was almost perfect for three observers for all regions and substantial for the observer with the lowest experience in LN3, local and visceral lesions (kappa: 0.74/0.79/0.62, respectively). Conclusion Interpretation of prostate-specific membrane antigen (PSMA) for prostate cancer is acceptably consistent among observers, but some details are noteworthy. The evaluation should be done more algorithmically for local tumors, since all observers showed relatively lower agreement. The agreement increased as prostate-specific antigen and Gleason score increased. The observer with PSMA experience <30 readings showed lower reliability, distinct from the others. This indicates that although a reader may be familiar with other PET agents, a more consistent interpretation of Ga-68-PSMA-PET/CT requires training with a small number of identified cases.
Açıklama
Anahtar Kelimeler
Agreement, Interobserver, Intraobserver, Prostate Cancer, PET, CT, Ga-68-Labeled Psma Ligand, Bone-Scintigraphy, Ga-68-Psma Pet/Ct, Metastases, Diagnosis, Pet/Mri
Kaynak
Nuclear Medicine Communications
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
42
Sayı
10
