PREVENTIVE EFFECTS OF ALPHA-LIPOIC ACID ON DIABETIC NEPHROPATHY IN A RAT MODEL

Basit Öğe Kaydı
dc.contributor.authorAyhan, Medina
dc.contributor.authorGuney, Engin
dc.contributor.authorAtile, Neslihan Soysal
dc.contributor.authorSerter, Mukadder
dc.contributor.authorMeteoglu, Ibrahim
dc.date.accessioned2024-06-12T10:51:20Z
dc.date.available2024-06-12T10:51:20Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Diabetic nephropathy is the major cause of chronic renal failure, and oxidative stress has an important role in its etiology. Aim of this study is to investigate the effects of the antioxidant alpha-lipoic acid (ALA) treatment on proteinuria, antioxidant enzyme and inflammatory cytokine levels in the renal tissue and renal histopathology in diabetes. Design: Thirty male Wistar rats were divided into three groups: normal control group (n=10), diabetic control group (n=10), and ALA treated diabetic group (n=10). Diabetes was induced by a single ultra venouse injection of streptozotocin. Rats which completed 4 weeks of the study period were sacrificed after 24 hour urine collection for albuminuria detection. Histopathological examination was performed. Antioxidant enzyme and inflammatory marker levels in renal tissue were measured. Results: The 24 hour urinary albumin levels were significantly reduced in the ALA-treated diabetic group compared with the diabetic control group. In ALA administered rats, histopathological findings such as tubular dilation, tubular epithelium necrosis, glomerular focal necrosis, and interstitial inflammation were observed at a lesser extent than the diabetic control group. Any difference was not detected between the diabetic control group, and the ALA group with respect to the levels of GSH, GSH-r, MDA, TNF-alpha and IL-6. Conclusion: ALA administration led to regression of histopathologic and morphologic lesions in extracted rat kidney. Also positive effect of ALA on albuminuria was detected. However, no positive effect of ALA was found for antioxidant parameters at the tissue level.en_US
dc.identifier.endpage1225en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue6en_US
dc.identifier.startpage1221en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18321
dc.identifier.volume30en_US
dc.identifier.wosWOS:000364114900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-Lipoic Aciden_US
dc.subjectDiabetes Mellitusen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidantsen_US
dc.subjectOxidative Stressen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectVitamin-Cen_US
dc.subjectAntioxidanten_US
dc.subjectSupplementationen_US
dc.subjectAlbuminuriaen_US
dc.subjectMetabolismen_US
dc.titlePREVENTIVE EFFECTS OF ALPHA-LIPOIC ACID ON DIABETIC NEPHROPATHY IN A RAT MODELen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu