PREVENTIVE EFFECTS OF ALPHA-LIPOIC ACID ON DIABETIC NEPHROPATHY IN A RAT MODEL
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Carbone Editore
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Diabetic nephropathy is the major cause of chronic renal failure, and oxidative stress has an important role in its etiology. Aim of this study is to investigate the effects of the antioxidant alpha-lipoic acid (ALA) treatment on proteinuria, antioxidant enzyme and inflammatory cytokine levels in the renal tissue and renal histopathology in diabetes. Design: Thirty male Wistar rats were divided into three groups: normal control group (n=10), diabetic control group (n=10), and ALA treated diabetic group (n=10). Diabetes was induced by a single ultra venouse injection of streptozotocin. Rats which completed 4 weeks of the study period were sacrificed after 24 hour urine collection for albuminuria detection. Histopathological examination was performed. Antioxidant enzyme and inflammatory marker levels in renal tissue were measured. Results: The 24 hour urinary albumin levels were significantly reduced in the ALA-treated diabetic group compared with the diabetic control group. In ALA administered rats, histopathological findings such as tubular dilation, tubular epithelium necrosis, glomerular focal necrosis, and interstitial inflammation were observed at a lesser extent than the diabetic control group. Any difference was not detected between the diabetic control group, and the ALA group with respect to the levels of GSH, GSH-r, MDA, TNF-alpha and IL-6. Conclusion: ALA administration led to regression of histopathologic and morphologic lesions in extracted rat kidney. Also positive effect of ALA on albuminuria was detected. However, no positive effect of ALA was found for antioxidant parameters at the tissue level.
Açıklama
Anahtar Kelimeler
Alpha-Lipoic Acid, Diabetes Mellitus, Diabetic Nephropathy, Oxidative Stress, Antioxidants, Oxidative Stress, Insulin-Resistance, Vitamin-C, Antioxidant, Supplementation, Albuminuria, Metabolism
Kaynak
Acta Medica Mediterranea
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
30
Sayı
6
