Frequency of RAS Mutations (KRAS, NRAS, HRAS) in Human Solid Cancer

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dc.authoridHacioglu, Bekir/0000-0001-8490-3239
dc.authoridHacıbekiroğlu, İlhan/0000-0002-0333-7405
dc.authorwosidHacioglu, Bekir/GZH-1824-2022
dc.authorwosidErdogan, Bulent/AAA-9781-2021
dc.authorwosidHacıbekiroğlu, İlhan/JCN-7264-2023
dc.contributor.authorKodaz, Hilmi
dc.contributor.authorKostek, Osman
dc.contributor.authorHacioglu, Muhammet Bekir
dc.contributor.authorErdogan, Bulent
dc.contributor.authorKodaz, Cagnur Elpen
dc.contributor.authorHacibekiroglu, Ilhan
dc.contributor.authorTurkmen, Esma
dc.date.accessioned2024-06-12T11:07:25Z
dc.date.available2024-06-12T11:07:25Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractRAS oncogene affects numerous cellular functions including growth, proliferation, apoptosis, migration, division and differentiation of the cells. It has 3 known isoforms as Harvey- RAS (HRAS), Kirsten - RAS (KRAS) and Neuroblastoma-RAS (NRAS). RAS has an intrinsic GTPase activity. It encodes proteins binding the guanine nucleotides. KRAS and HRAS were discovered in studies carried out on viruses leading to cancer. Retroviral oncogenes related to murine sarcoma virus genes (Kristen Rat Sarcoma Virus and Murine Sarcoma Virus) were discovered in 1982. These two oncogenes are similar to human KRAS. Approximately 30% of all human cancers have ras genes. Mutations in KRAS account for about 85% for all RAS mutations in human tumors, NRAS is about 11-15%, and HRAS is about 1%.en_US
dc.identifier.doi10.14744/ejmo.2017.22931
dc.identifier.endpage7en_US
dc.identifier.issn2587-196X
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.14744/ejmo.2017.22931
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22031
dc.identifier.volume1en_US
dc.identifier.wosWOS:000604198100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofEurasian Journal Of Medicine And Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKRASen_US
dc.subjectNRASen_US
dc.subjectHRASen_US
dc.subjectCanceren_US
dc.subjectK-Rasen_US
dc.subjectBraf Mutationsen_US
dc.subjectH-Rasen_US
dc.subjectPoint Mutationsen_US
dc.subjectOncogenic Mutationsen_US
dc.subjectCell Carcinomaen_US
dc.subjectN-Rasen_US
dc.subjectGenomic Characterizationen_US
dc.subjectGene-Mutationsen_US
dc.subjectActivationen_US
dc.titleFrequency of RAS Mutations (KRAS, NRAS, HRAS) in Human Solid Canceren_US
dc.typeReview Articleen_US

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