Frequency of RAS Mutations (KRAS, NRAS, HRAS) in Human Solid Cancer
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kare Publ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
RAS oncogene affects numerous cellular functions including growth, proliferation, apoptosis, migration, division and differentiation of the cells. It has 3 known isoforms as Harvey- RAS (HRAS), Kirsten - RAS (KRAS) and Neuroblastoma-RAS (NRAS). RAS has an intrinsic GTPase activity. It encodes proteins binding the guanine nucleotides. KRAS and HRAS were discovered in studies carried out on viruses leading to cancer. Retroviral oncogenes related to murine sarcoma virus genes (Kristen Rat Sarcoma Virus and Murine Sarcoma Virus) were discovered in 1982. These two oncogenes are similar to human KRAS. Approximately 30% of all human cancers have ras genes. Mutations in KRAS account for about 85% for all RAS mutations in human tumors, NRAS is about 11-15%, and HRAS is about 1%.
Açıklama
Anahtar Kelimeler
KRAS, NRAS, HRAS, Cancer, K-Ras, Braf Mutations, H-Ras, Point Mutations, Oncogenic Mutations, Cell Carcinoma, N-Ras, Genomic Characterization, Gene-Mutations, Activation
Kaynak
Eurasian Journal Of Medicine And Oncology
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
1
Sayı
1
