A comparison of the effect on gastric emptying of propofol or dexmedetomidine in critically ill patients

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dc.contributor.authorMemis, D.
dc.contributor.authorDokmeci, D.
dc.contributor.authorKaramanlioglu, B.
dc.contributor.authorTuran, A.
dc.contributor.authorTure, M.
dc.date.accessioned2024-06-12T11:02:31Z
dc.date.available2024-06-12T11:02:31Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Propofol and dexmedetomidine are widely used for sedation in the intensive care unit yet there are limited data on its effects on gastric motility. In our preliminary study, we examined whether or not any effect of propofol and dexmedetomidine on gastric emptying is preserved in critically ill patients. Methods: Twenty-four critically ill, enterally fed adult patients each received enteral feeding via a nasogastric tube at 50 mL h(-1) throughout the 5-h study period. Either propofol 2 mg kg(-1) h(-1) (n = 12, Group P) or dexmedetomidine 0.2 mu g kg(-1) h(-1) (n = 12, Group D) was given intravenously over 5h. Gastric motility was measured indirectly by analysis of the absorption over time of 1.5 g of paracetamol administered into the stomach at the start of the study period. At the beginning and end of the study, residual gastric volume and pH of residual gastric fluid were measured. Results: Gastric residual volume measured at the end of propofol infusion (19.33 +/- 11.33) was found to be higher when compared with the volume measured before infusion (11.33 +/- 4.84) and after dexmedetomidine infusion (9.17 +/- 4.54). But, there was no difference between groups in gastric emptying time (AUC120 894.53 +/- 499.39 vs. 1113.46 +/- 598-09 propofol and dexmedetomidine groups, respectively). Conclusion: In our study, gastric residual volume measured at the end of propofol infusion was found to be higher when compared with the volume measured before infusion and after dexmedetomidine infusion. There was no difference between groups in gastric emptying time.en_US
dc.identifier.doi10.1017/S0265021506000512
dc.identifier.endpage704en_US
dc.identifier.issn0265-0215
dc.identifier.issue8en_US
dc.identifier.pmid16805936en_US
dc.identifier.scopus2-s2.0-33745684466en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage700en_US
dc.identifier.urihttps://doi.org/10.1017/S0265021506000512
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21296
dc.identifier.volume23en_US
dc.identifier.wosWOS:000239400900012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofEuropean Journal Of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastric Emptyingen_US
dc.subjectPropofolen_US
dc.subjectDexmedetomidineen_US
dc.subjectCritical Illnessen_US
dc.subjectCritical Care.en_US
dc.subjectParacetamol Absorptionen_US
dc.subjectMotilityen_US
dc.subjectSedationen_US
dc.subjectClonidineen_US
dc.subjectSystemen_US
dc.titleA comparison of the effect on gastric emptying of propofol or dexmedetomidine in critically ill patientsen_US
dc.typeArticleen_US

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