A comparison of the effect on gastric emptying of propofol or dexmedetomidine in critically ill patients
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cambridge Univ Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Propofol and dexmedetomidine are widely used for sedation in the intensive care unit yet there are limited data on its effects on gastric motility. In our preliminary study, we examined whether or not any effect of propofol and dexmedetomidine on gastric emptying is preserved in critically ill patients. Methods: Twenty-four critically ill, enterally fed adult patients each received enteral feeding via a nasogastric tube at 50 mL h(-1) throughout the 5-h study period. Either propofol 2 mg kg(-1) h(-1) (n = 12, Group P) or dexmedetomidine 0.2 mu g kg(-1) h(-1) (n = 12, Group D) was given intravenously over 5h. Gastric motility was measured indirectly by analysis of the absorption over time of 1.5 g of paracetamol administered into the stomach at the start of the study period. At the beginning and end of the study, residual gastric volume and pH of residual gastric fluid were measured. Results: Gastric residual volume measured at the end of propofol infusion (19.33 +/- 11.33) was found to be higher when compared with the volume measured before infusion (11.33 +/- 4.84) and after dexmedetomidine infusion (9.17 +/- 4.54). But, there was no difference between groups in gastric emptying time (AUC120 894.53 +/- 499.39 vs. 1113.46 +/- 598-09 propofol and dexmedetomidine groups, respectively). Conclusion: In our study, gastric residual volume measured at the end of propofol infusion was found to be higher when compared with the volume measured before infusion and after dexmedetomidine infusion. There was no difference between groups in gastric emptying time.
Açıklama
Anahtar Kelimeler
Gastric Emptying, Propofol, Dexmedetomidine, Critical Illness, Critical Care., Paracetamol Absorption, Motility, Sedation, Clonidine, System
Kaynak
European Journal Of Anaesthesiology
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
23
Sayı
8
