Compound 48/80, a histamine-depleting agent, blocks the protective effect of morphine against electroconvulsive shock in mice

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dc.authoridDost, Turhan/0000-0001-7547-3310
dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidDost, Turhan/B-3088-2012
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorKaradag, CH
dc.contributor.authorDokmeci, D
dc.contributor.authorDost, T
dc.contributor.authorUlugol, A
dc.contributor.authorDokmeci, I
dc.date.accessioned2024-06-12T11:08:43Z
dc.date.available2024-06-12T11:08:43Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe have shown that morphine has an anticonvulsive effect against maximal electroconvulsive shock (MES) in mice, and this effect is antagonized by histamine Hi-receptor antagonists. Brain histamine is localized both in neurons and in mast cells, and morphine is known to enhance the turnover of neuronal histamine and to release histamine from mast cells. In the present experiments, compound 48/80 was injected chronically (0.5 mg/kg on day 1, 1 mg/kg on day 2, 2 mg/kg on day 3, 3 mg/kg on day 4, and 4 mg/kg on day 5, twice daily, ip) to deplete mast cell contents. Morphine (0.001-10 mg/kg, ip; N = 20) produced a dose-dependent anticonvulsive effect against MES seizure in mice with non-depleted mast cells, whereas it did not exert any anticonvulsive effect in mice with depleted mast cells. These results indicate that morphine produces its anticonvulsive effect against maximal electroconvulsive shock in mice by liberating histamine from mast cells.en_US
dc.identifier.doi10.1590/S0100-879X2000000300011
dc.identifier.endpage330en_US
dc.identifier.issn0100-879X
dc.identifier.issue3en_US
dc.identifier.pmid10719385en_US
dc.identifier.scopus2-s2.0-0034118194en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage327en_US
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2000000300011
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22541
dc.identifier.volume33en_US
dc.identifier.wosWOS:000086131000011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Bras Divulg Cientificaen_US
dc.relation.ispartofBrazilian Journal Of Medical And Biological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMorphineen_US
dc.subjectAnticonvulsive Effecten_US
dc.subjectHistamineen_US
dc.subjectMast Cellsen_US
dc.subjectCompound 48/80en_US
dc.subjectElectroshocken_US
dc.subjectElectrically-Induced Convulsionsen_US
dc.subjectCentral Nervous-Systemen_US
dc.subjectMast-Cellsen_US
dc.subjectReceptor Antagonisten_US
dc.subjectBrain Histamineen_US
dc.subjectMouse-Brainen_US
dc.subjectRaten_US
dc.subjectTransmitteren_US
dc.subjectReleaseen_US
dc.titleCompound 48/80, a histamine-depleting agent, blocks the protective effect of morphine against electroconvulsive shock in miceen_US
dc.typeArticleen_US

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