Compound 48/80, a histamine-depleting agent, blocks the protective effect of morphine against electroconvulsive shock in mice
Küçük Resim Yok
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Assoc Bras Divulg Cientifica
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We have shown that morphine has an anticonvulsive effect against maximal electroconvulsive shock (MES) in mice, and this effect is antagonized by histamine Hi-receptor antagonists. Brain histamine is localized both in neurons and in mast cells, and morphine is known to enhance the turnover of neuronal histamine and to release histamine from mast cells. In the present experiments, compound 48/80 was injected chronically (0.5 mg/kg on day 1, 1 mg/kg on day 2, 2 mg/kg on day 3, 3 mg/kg on day 4, and 4 mg/kg on day 5, twice daily, ip) to deplete mast cell contents. Morphine (0.001-10 mg/kg, ip; N = 20) produced a dose-dependent anticonvulsive effect against MES seizure in mice with non-depleted mast cells, whereas it did not exert any anticonvulsive effect in mice with depleted mast cells. These results indicate that morphine produces its anticonvulsive effect against maximal electroconvulsive shock in mice by liberating histamine from mast cells.
Açıklama
Anahtar Kelimeler
Morphine, Anticonvulsive Effect, Histamine, Mast Cells, Compound 48/80, Electroshock, Electrically-Induced Convulsions, Central Nervous-System, Mast-Cells, Receptor Antagonist, Brain Histamine, Mouse-Brain, Rat, Transmitter, Release
Kaynak
Brazilian Journal Of Medical And Biological Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
33
Sayı
3
