Complex Nature of Neural Tube Defects: A Regional Experience

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dc.contributor.authorTurhan, Emrah
dc.contributor.authorVarol, Fusun G.
dc.contributor.authorGurkan, Hakan
dc.contributor.authorSayın, N. Cenk
dc.date.accessioned2024-06-12T10:04:24Z
dc.date.available2024-06-12T10:04:24Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: The underlying gene-environment interaction of fetal neural tube defects is affected byseveral factors including geography, ethnicity and time. Local features of fetal neural tube defects weredescribed.STUDY DESIGN: A prospective cohort study of 48 fetal neural tube defects in a single tertiary medicalcenter at the northwestern region of Turkey (2013-2015) was done via ultrasound, magnetic resonanceimaging (MRI), conventional karyotyping, maternal methylenetetrahydrofolate reductase c.677C>T(rs1801133) single-nucleotide polymorphism and maternal serum levels of folic acid, vitamin B12 andzinc. For comparison of means, a Student’s T-Test was used.RESULTS: The prevalence of neural tube defects was 11.4 per 10000 births (48/42000) in northwesternTurkey. The defects on the cranium (n=23; 47.9%) and spine (n=25; 52.1%) were ultrasonographicallydetected. MRI did not give additional benefit over the ultrasonography. The ratio of associated anomaliesin neural tube defect group was 25%. Two fetal neural tube defects with Down syndrome were remarkable. The rate of homozygous methylenetetrahydrofolate reductase c.677C > T SNPs among the mothersof neural tube defect fetuses (n=20) was 15%. Comparing with gestationally matched healthy pregnancies, although maternal BMIs and periconceptional folate intake of neural tube defect group were significantly different, maternal serum folic acid, vitamin B12 and zinc levels were similar.CONCLUSION: The northwestern region appeared to be a relatively low prevalence area of Turkey forfetal neural tube defects. Any association with maternal serum folic acid, vitamin B12 and zinc levelscould not be shown in this region.en_US
dc.identifier.doi10.21613/GORM.2017.769
dc.identifier.endpage123en_US
dc.identifier.issn1300-4751
dc.identifier.issn2602-4918
dc.identifier.issue3en_US
dc.identifier.startpage119en_US
dc.identifier.trdizinid379828en_US]
dc.identifier.urihttps://doi.org/10.21613/GORM.2017.769
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/379828
dc.identifier.urihttps://hdl.handle.net/20.500.14551/12818
dc.identifier.volume24en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofGORM:Gynecology Obstetrics & Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleComplex Nature of Neural Tube Defects: A Regional Experienceen_US
dc.typeArticleen_US

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