Complex Nature of Neural Tube Defects: A Regional Experience
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Tarih
2018
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
OBJECTIVE: The underlying gene-environment interaction of fetal neural tube defects is affected byseveral factors including geography, ethnicity and time. Local features of fetal neural tube defects weredescribed.STUDY DESIGN: A prospective cohort study of 48 fetal neural tube defects in a single tertiary medicalcenter at the northwestern region of Turkey (2013-2015) was done via ultrasound, magnetic resonanceimaging (MRI), conventional karyotyping, maternal methylenetetrahydrofolate reductase c.677C>T(rs1801133) single-nucleotide polymorphism and maternal serum levels of folic acid, vitamin B12 andzinc. For comparison of means, a Student’s T-Test was used.RESULTS: The prevalence of neural tube defects was 11.4 per 10000 births (48/42000) in northwesternTurkey. The defects on the cranium (n=23; 47.9%) and spine (n=25; 52.1%) were ultrasonographicallydetected. MRI did not give additional benefit over the ultrasonography. The ratio of associated anomaliesin neural tube defect group was 25%. Two fetal neural tube defects with Down syndrome were remarkable. The rate of homozygous methylenetetrahydrofolate reductase c.677C > T SNPs among the mothersof neural tube defect fetuses (n=20) was 15%. Comparing with gestationally matched healthy pregnancies, although maternal BMIs and periconceptional folate intake of neural tube defect group were significantly different, maternal serum folic acid, vitamin B12 and zinc levels were similar.CONCLUSION: The northwestern region appeared to be a relatively low prevalence area of Turkey forfetal neural tube defects. Any association with maternal serum folic acid, vitamin B12 and zinc levelscould not be shown in this region.
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Kaynak
GORM:Gynecology Obstetrics & Reproductive Medicine
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Cilt
24
Sayı
3
