A new strategy for direct solution electrospinning of phosphorylated poly (vinyl chloride)/polyethyleneimine blend in alcohol media
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Phosphorylated poly(vinyl chloride) (PPVC)/polyethyleneimine (PEI)-based nanofibers were produced via electrospinning in their blended solutions for the first time. For this purpose, PVC was partially converted into PVC-N3 and the PVC-N3 is then reacted with bis(diethoxyphosphoryl) acetylene (BDPA) via metal-free azide--alkyne 1,3-dipolar cycloaddition reaction to achieve the alcohol-soluble PPVC. PPVC and PEI solutions at certain concentrations prepared in methanol were electrospun from a single syringe at 90/10 and 85/15 vol ratios without phase separation. The accuracy of the modifications conducted on PVC was proven by Fourier-transform infrared (FT-IR), proton and carbon nuclear magnetic resonance (1H NMR and 13C NMR) spectros-copies and gel permeation chromatography (GPC), respectively. The achieved nanofibers and their intermediates were characterized by scanning electron microscope (SEM), water contact angle (WCA) measurement, ther-mogravimetric (TGA) and differential scanning calorimetry (DSC) analyses.The blood interaction of PPVC-PEI was evaluated through hemolysis and platelet activation assay, since most of the biomedical applications of PVC derivatives have close contact with blood. The results showed that PPVC-PEI nanofibers provide a safer surface for platelet with lower hemolytic activity compared to PPVC nanofibers. Therefore, PPVC-PEI-based electrospun nanofibers obtained by such an effective strategy exhibited a promising perspective for scientists in various biomedical purposes.
Açıklama
Anahtar Kelimeler
Blood-Contacting, Electrospinning, Metal-Freeazide-Alkyne 13-Dipolar Cycloaddi-Tion, Poly (Vinyl Chloride), Polyethyleneimine, Poly(Vinyl Chloride), Polyethyleneimine, Nanofibers, Nanoparticles, Pvc, Poly(Ethyleneimine), Immobilization, Fabrication, Particles, Membranes
Kaynak
European Polymer Journal
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
183
