Investigations on antimicrobial and antitubercular activity of some 4,5-dihydro-1h-pyrazole and chalcone derivatives

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dc.authorscopusid56094441300
dc.authorscopusid23034973800
dc.authorscopusid24757862800
dc.authorscopusid56008687100
dc.contributor.authorEvranos Aksöz B.
dc.contributor.authorKaynak Onurdağ F.
dc.contributor.authorAksöz E.
dc.contributor.authorÖzgen Özgacar S.
dc.date.accessioned2024-06-12T10:25:59Z
dc.date.available2024-06-12T10:25:59Z
dc.date.issued2021
dc.description.abstractObjective: In this study, first of all, chalcones and the compounds in the structure of 4,5-dihydro-1H-pyrazole, which are formed by ring closure as a result of the reaction of the chalcones with hydrazides were synthesized and the antimicrobial and antitubercular effects of all synthesized compounds were investigated. Material and Method: 4,5-Dihydro-1H-pyrazole derivatives were obtained as a result of the reaction of chalcones acquired by the reaction of benzaldehyde and acetophenone derivatives in methanol in alkaline medium, with hydrazide derivatives in methanol. The antimicrobial effects of these synthesized compounds were determined by microdilution method and their antitubercular effects were determined by microplate alamar blue assay. Result and Discussion: Compounds in the structure of 4,5-dihydro-1H-pyrazole were found to be more effective than chalcones against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Pseudomonas aeruginosa isolate (gentamicin resistant) and Candida albicans. Against the strain of Staphylococcus aureus, chalcones were found to be more effective than 4,5-dihydro-1H-pyrazole derivatives. Both chalcones and 4,5-dihydro-1H-pyrazole derivatives showed similar effect against Staphylococcus aureus isolate (MRSA) and Mycobacterium tuberculosis. Compound B21 had the same activity with fluconazole against Candida krusei. Compound B20 was found to be more effective than fluconazole against Candida krusei. © 2021 University of Ankara. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.870815
dc.identifier.endpage237en_US
dc.identifier.issn2564-6524
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85114063357en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.870815
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16612
dc.identifier.volume45en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject4; 5-Dihydro-1h-Pyrazole; Antimicrobial Activity; Antitubercular Activity; Chalconeen_US
dc.subject4,5 Dihydro 1h Pyrazole; Acetophenone Derivative; Benzaldehyde; Chalcone Derivative; Fluconazole; Gentamicin; Hydrazide; Hydrazide Derivative; Methanol; Pyrazole Derivative; Unclassified Drug; Unclassified Drug; Antibiotic Resistance; Antimicrobial Activity; Article; Bacterial Strain; Bacterium Isolate; Broth Dilution; Candida Albicans; Drug Synthesis; Escherichia Coli; Methicillin Resistant Staphylococcus Aureus; Mycobacterium Tuberculosis; Nonhuman; Pichia Kudriavzevii; Pseudomonas Aeruginosa; Resazurin Assay; Staphylococcus Aureusen_US
dc.titleInvestigations on antimicrobial and antitubercular activity of some 4,5-dihydro-1h-pyrazole and chalcone derivativesen_US
dc.title.alternativeBazi 4,5-dİhİdro-1h-pİrazol ve şalkon türevlerİnİn antİmİkrobİyal ve antİtüberküler etkİlerİ üzerİne araştirmalaren_US
dc.typeArticleen_US

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